Impact of adverse drug reactions on the treatment pathways of early rheumatoid arthritis patients: a prospective observational cohort study

Kimberly Velthuis*, Fenna Poppelaars, Peter M. ten Klooster, Harald E. Vonkeman, Naomi T. Jessurun

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
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Abstract

Background: Several patient characteristics may be of influence on treatment pathways of rheumatoid arthritis (RA) patients in clinical practice. The aim of this study is to analyze treatment pathways of early RA patients stratified for gender and adverse drug reaction (ADR) occurrence.
Research design and methods: Treatment pathways of patients included in the DREAM-RA treat-to-target cohort I between 16th of July 2006-30th of April 2020 were assessed. Treatment pathways were visualized in Sankey diagrams. Follow-up time, duration per treatment and the number of treatments received were stratified for gender and ADR occurrence and analyzed. Independent t-tests and chi-square tests were performed where applicable.
Results: Treatment pathways of 372 patients (follow-up: 2488.4 years, mean 6.7±3.7 years) were analyzed. The Sankey diagrams visualize that treatment pathways became increasingly varied and complex over time. No significant differences were found when comparing female patients and male patients. However, the average treatment duration was shorter in patients with ADRs (1.8 vs. 2.7 years, pConclusions: Treatment pathways increase in complexity over time. Differences were found between patients with and without ADRs, with patients that experience ADRs receiving more and shorter treatments.
Original languageEnglish
Pages (from-to)753-762
Number of pages10
JournalExpert opinion on drug safety
Volume22
Issue number8
Early online date24 Mar 2023
DOIs
Publication statusPublished - 3 Aug 2023

Keywords

  • DMARDs
  • adverse drug reactions
  • real-world data
  • rheumatoid arthritis
  • treat-to-target
  • treatment pathways

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