Impact of analyzing less image frames per segment for radiofrequency-based volumetric intravascular ultrasound measurements in mild-to-moderate coronary atherosclerosis

Jennifer Huisman, Marc Hartmann, Eline S. Mattern, Gary S. Mintz, Mounir W.Z. Basalus, Gert K. van Houwelingen, Patrick M.J. Verhorst, Clemens von Birgelen

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Abstract

Volumetric radiofrequency-based intravascular ultrasound (RF–IVUS) data of coronary segments are increasingly used as endpoints in serial trials of novel anti-atherosclerotic therapies. In a relatively time-consuming process, vessel and lumen contours are defined; these contours are first automatically detected, then visually checked, and finally (in most cases) manually edited to generate reliable volumetric data of vessel geometry and plaque composition. Reduction in number of cross-sectional images for volumetric analysis could save analysis time but may also increase measurement variability of volumetric data. To assess whether a 50% reduction in number of frames per segment (every second frame) alters the reproducibility of volumetric measurements, we performed repeated RF–IVUS analyses of 15 coronary segments with mild-to-moderate atherosclerosis (20.2 ± 0.2 mm-long segments with 46 ± 13% plaque burden). Volumes were calculated based on a total of 731 image frames. Reducing the number of cross-sectional image frames for volumetric measurements saved analysis time (38 ± 9 vs. 68 ± 17 min/segment; P < 0.0001) and resulted for only a few parameters in (borderline) significant but mild differences versus measurements based on all frames (fibrous volume, P < 0.05; necrotic-core volume, P = 0.07). Compared to the intra-observer variability, there was a mild increase in measurement variability for most geometrical and compositional volumetric RF–IVUS parameters. In RF–IVUS studies of mild-to-moderate coronary disease, analyzing less image frames saved analysis time, left most volumetric parameters greatly unaffected, and resulted in a no more than mild increase in measurement variability of volumetric data.
Original languageEnglish
Pages (from-to)487-497
Number of pages11
JournalInternational journal of cardiovascular imaging
Volume26
Issue number5
DOIs
Publication statusPublished - 2010

Fingerprint

Coronary Artery Disease
Observer Variation
Coronary Disease
Atherosclerosis
Therapeutics

Keywords

  • METIS-269205
  • Intravascular ultrasound
  • Radiofrequency
  • Virtual histology
  • Plaque composition
  • Necrotic core
  • Vulnerable plaque
  • IVUS
  • VH-IVUS
  • Reproducibility
  • Variability
  • Atherosclerosis
  • Coronary artery disease
  • Coronary vessels

Cite this

Huisman, Jennifer ; Hartmann, Marc ; Mattern, Eline S. ; Mintz, Gary S. ; Basalus, Mounir W.Z. ; van Houwelingen, Gert K. ; Verhorst, Patrick M.J. ; von Birgelen, Clemens. / Impact of analyzing less image frames per segment for radiofrequency-based volumetric intravascular ultrasound measurements in mild-to-moderate coronary atherosclerosis. In: International journal of cardiovascular imaging. 2010 ; Vol. 26, No. 5. pp. 487-497.
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abstract = "Volumetric radiofrequency-based intravascular ultrasound (RF–IVUS) data of coronary segments are increasingly used as endpoints in serial trials of novel anti-atherosclerotic therapies. In a relatively time-consuming process, vessel and lumen contours are defined; these contours are first automatically detected, then visually checked, and finally (in most cases) manually edited to generate reliable volumetric data of vessel geometry and plaque composition. Reduction in number of cross-sectional images for volumetric analysis could save analysis time but may also increase measurement variability of volumetric data. To assess whether a 50{\%} reduction in number of frames per segment (every second frame) alters the reproducibility of volumetric measurements, we performed repeated RF–IVUS analyses of 15 coronary segments with mild-to-moderate atherosclerosis (20.2 ± 0.2 mm-long segments with 46 ± 13{\%} plaque burden). Volumes were calculated based on a total of 731 image frames. Reducing the number of cross-sectional image frames for volumetric measurements saved analysis time (38 ± 9 vs. 68 ± 17 min/segment; P < 0.0001) and resulted for only a few parameters in (borderline) significant but mild differences versus measurements based on all frames (fibrous volume, P < 0.05; necrotic-core volume, P = 0.07). Compared to the intra-observer variability, there was a mild increase in measurement variability for most geometrical and compositional volumetric RF–IVUS parameters. In RF–IVUS studies of mild-to-moderate coronary disease, analyzing less image frames saved analysis time, left most volumetric parameters greatly unaffected, and resulted in a no more than mild increase in measurement variability of volumetric data.",
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Impact of analyzing less image frames per segment for radiofrequency-based volumetric intravascular ultrasound measurements in mild-to-moderate coronary atherosclerosis. / Huisman, Jennifer; Hartmann, Marc; Mattern, Eline S.; Mintz, Gary S.; Basalus, Mounir W.Z.; van Houwelingen, Gert K.; Verhorst, Patrick M.J.; von Birgelen, Clemens.

In: International journal of cardiovascular imaging, Vol. 26, No. 5, 2010, p. 487-497.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Huisman, Jennifer

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AU - Mattern, Eline S.

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AU - Basalus, Mounir W.Z.

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AB - Volumetric radiofrequency-based intravascular ultrasound (RF–IVUS) data of coronary segments are increasingly used as endpoints in serial trials of novel anti-atherosclerotic therapies. In a relatively time-consuming process, vessel and lumen contours are defined; these contours are first automatically detected, then visually checked, and finally (in most cases) manually edited to generate reliable volumetric data of vessel geometry and plaque composition. Reduction in number of cross-sectional images for volumetric analysis could save analysis time but may also increase measurement variability of volumetric data. To assess whether a 50% reduction in number of frames per segment (every second frame) alters the reproducibility of volumetric measurements, we performed repeated RF–IVUS analyses of 15 coronary segments with mild-to-moderate atherosclerosis (20.2 ± 0.2 mm-long segments with 46 ± 13% plaque burden). Volumes were calculated based on a total of 731 image frames. Reducing the number of cross-sectional image frames for volumetric measurements saved analysis time (38 ± 9 vs. 68 ± 17 min/segment; P < 0.0001) and resulted for only a few parameters in (borderline) significant but mild differences versus measurements based on all frames (fibrous volume, P < 0.05; necrotic-core volume, P = 0.07). Compared to the intra-observer variability, there was a mild increase in measurement variability for most geometrical and compositional volumetric RF–IVUS parameters. In RF–IVUS studies of mild-to-moderate coronary disease, analyzing less image frames saved analysis time, left most volumetric parameters greatly unaffected, and resulted in a no more than mild increase in measurement variability of volumetric data.

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KW - Radiofrequency

KW - Virtual histology

KW - Plaque composition

KW - Necrotic core

KW - Vulnerable plaque

KW - IVUS

KW - VH-IVUS

KW - Reproducibility

KW - Variability

KW - Atherosclerosis

KW - Coronary artery disease

KW - Coronary vessels

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