Impact of gender and age on 3-year clinical outcome and chest pain of patients with coronary artery disease treated with contemporary drug-eluting stents: A patient-level pooled analysis

Marlies Kok, Liefke van der Heijden, Marijke Lowik, Paolo Zocca, Carine J. M. Doggen, Peter Danse, Rutger L. Anthonio, Marc Hartmann, Gerard C.M. Linssen, Angela Maas, Roxana Mehran, C Von Birgelen

Research output: Contribution to journalArticleAcademic

Abstract

BACKGROUND Women report more often chest pain following percutaneous coronary intervention (PCI), yet little is known about the impact of age on these symptoms. We aimed to assess age and gender-related differences in chest pain following PCI with newergeneration drug-eluting stents (DES). METHODS A patient-level pooled analysis of the TWENTE and DUTCH PEERS randomized trials (NCT01066650; NCT01331707) was performed, in which patients were treated with newer generation permanent polymer DES. The primary endpoint of both studies was target vessel failure (TVF); secondary endpoints included MACE (composite of any death, any myocardial infarction (MI), emergent CABG or target lesion revascularization) and POCE (composite of any death, any MI and any revascularization). RESULTS Clinical follow-up was available in 3,188 patients (99.8%). Women had more risk factors including diabetes (24.2% vs. 17.8%, p65 years. Women 65 years, both women and men reported similar levels of chest pain at rest or mild exertion (8.8% and 8.7%, p=0.76); in this subgroup gender did not independently predict chest pain (adjusted OR 1.27 95%-CI:0.8-1.9, p=0.26). Nevertheless, in women and men similar 3-year rates of TVF, MACE, and POCE were found (11.6% vs. 11.3%, p=0.81; 13.6% vs. 12.5%, p=0.43; 18.8% vs. 18.0%, p=0.60, respectively). CONCLUSION While for both genders the incidence of adverse cardiovascular events was low and similar, women
Original languageEnglish
Pages (from-to)B146
JournalJournal of the American College of Cardiology
Volume68
Issue number18 Supplement
DOIs
Publication statusPublished - Nov 2016

Keywords

  • aged
  • clinical outcome
  • controlled clinical trial
  • controlled study
  • coronary artery disease
  • death
  • diabetes mellitus
  • disease course
  • drug eluting stent
  • exercise
  • family study
  • female
  • follow up
  • gender
  • heart infarction
  • human
  • hypertension
  • male
  • meta analysis
  • multivariate analysis
  • percutaneous coronary intervention
  • polymer
  • prevalence
  • randomized controlled trial
  • rest
  • revascularization
  • risk factor
  • thorax pain

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