Impact of Gender on Femoral Access Complications Secondary to Application of a Collagen-based Vascular Closure Device

Holger Eggebrecht* (Corresponding Author), Clemens Von Birgelen, Christoph Naber, Knut Kröger, Axel Schmermund, Heinrich Wieneke, Thomas Bartel, Uta Wörtgen, Dietrich Baumgart, Michael Haude, Raimund Erbel

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    31 Citations (Scopus)

    Abstract

    Background: Vascular complications at the femoral access site continue to be a significant problem after cardiac catheterization procedures. It was the aim of the present study to assess the impact of gender on the incidence of severe femoral access complications following the application of a collagen-based vascular closure device after transfemoral catheterization procedure. Methods: A total of 1294 consecutive patients (977 male, 317 female) underwent closure of femoral access sites with 8F collagen-based vascular closure devices (Angioseal™) immediately after diagnostic or interventional coronary catheterization procedures, independently of the coagulation status. All patients were closely monitored for the occurrence of complications during the following 24 hours. Results: Between male and female patients, there was no difference in the technical performance of the device with successful deployment being achieved in 96.7% and 95.9%, respectively (p=0.60). Severe access complications were found to be significantly higher in female versus male patients (1.6% vs. 0.2%; Odds ratio 7.7, 95% confidence interval 1.5-40.1; p = 0.015), although similar accomplishment of an immediate hemostasis was seen in 92.8% and 92.4% of male and female patients (p=0.98). Conclusion: Women show a significantly increased risk of developing severe femoral access complications secondary to the application of a collagen-based vascular closure device, although the overall incidence of these complications is relatively low. We speculate that the increased risk in women may be related to smaller arterial dimensions, which could be evaluated by femoral angiography prior to deployment of a closure device.

    Original languageEnglish
    Pages (from-to)247-250
    Number of pages4
    JournalJournal of Invasive Cardiology
    Volume16
    Issue number5
    Publication statusPublished - 1 May 2004

    Keywords

    • Bleeding
    • Catheterization
    • Closure device
    • Female
    • Femoral
    • Gender
    • Vascular access complications

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