Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

Deepti Rana; Sanjay Kumar; Thomas J. Webster; Murugan Ramalingam

doi:10.1007/s11914-019-00519-9

Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

Deepti Rana, Sanjay Kumar, Thomas J. Webster^*, Murugan Ramalingam

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

37 Citations (Scopus)

34 Downloads (Pure)

Abstract

Purpose of Review: The main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration. Recent Findings: Pluripotent stem cell–based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications. Summary: This review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.

Original language	English
Pages (from-to)	226-234
Number of pages	9
Journal	Current Osteoporosis Reports
Volume	17
Issue number	4
DOIs	https://doi.org/10.1007/s11914-019-00519-9
Publication status	Published - 15 Aug 2019

Keywords

Biomaterials
Bone regeneration
Bone tissue engineering
Induced pluripotent stem cells (iPSCs)
Osteogenic differentiation
n/a OA procedure

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10.1007/s11914-019-00519-9

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title = "Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration",

abstract = "Purpose of Review: The main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration. Recent Findings: Pluripotent stem cell–based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications. Summary: This review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.",

keywords = "Biomaterials, Bone regeneration, Bone tissue engineering, Induced pluripotent stem cells (iPSCs), Osteogenic differentiation, n/a OA procedure",

author = "Deepti Rana and Sanjay Kumar and Webster, {Thomas J.} and Murugan Ramalingam",

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T1 - Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

AU - Rana, Deepti

AU - Kumar, Sanjay

AU - Webster, Thomas J.

AU - Ramalingam, Murugan

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Purpose of Review: The main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration. Recent Findings: Pluripotent stem cell–based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications. Summary: This review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.

AB - Purpose of Review: The main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration. Recent Findings: Pluripotent stem cell–based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications. Summary: This review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.

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KW - Bone tissue engineering

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Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

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