Impact of interactions between drugs and laboratory test results on diagnostic test interpretation - a systematic review

Jasmijn A. van Balveren, Willemine Verboeket-Van de Venne, Lale Erdem-Eraslan, Albert J. de Graaf, Annemarieke E. Loot, Ruben E.A. Musson, Wytze P. Oosterhuis, Martin P. Schuijt, Heleen van der Sijs, Rolf J. Verheul, Holger K. de Wolf, Ron Kusters, Rein M.J. Hoedemakers

Research output: Contribution to journalReview articleAcademicpeer-review

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Intake of drugs may influence the interpretation of laboratory test results. Knowledge and correct interpretation of possible drug-laboratory test interactions (DLTIs) is important for physicians, pharmacists and laboratory specialists. Laboratory results may be affected by analytical or physiological effects of medication. Failure to take into account the possible unintended influence of drug use on a laboratory test result may lead to incorrect diagnosis, incorrect treatment and unnecessary follow-up. The aim of this review is to give an overview of the literature investigating the clinical impact and use of DLTI decision support systems on laboratory test interpretation. Particular interactions were reported in a large number of articles, but they were fragmentarily described and some papers even reported contradictory findings. To provide an overview of information that clinicians and laboratory staff need to interpret test results, DLTI databases have been made by several groups. In a literature search, only four relevant studies have been found on DLTI decision support applications for laboratory test interpretation in clinical practice. These studies show a potential benefit of automated DLTI messages to physicians for the correct interpretation of laboratory test results. Physicians reported 30-100% usefulness of DLTI messages. In one study 74% of physicians sometimes even refrained from further additional examination. The benefit of decision support increases when a refined set of clinical rules is determined in cooperation with health care professionals. The prevalence of DLTIs is high in a broad range of combinations of laboratory tests and drugs and these frequently remain unrecognized.
Original languageEnglish
Article number56
Pages (from-to)2004-2009
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Issue number12
Publication statusPublished - Dec 2018


  • UT-Hybrid-D
  • Clinical laboratory test
  • Diagnostic error
  • Drug laboratory test interaction
  • Patient safety
  • (Computerized) clinical decision support


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