TY - JOUR
T1 - Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis
AU - Crowson, Cynthia S.
AU - Rollefstad, Silvia
AU - Ikdahl, Eirik
AU - Kitas, George D.
AU - van Riel, Piet L.C.M.
AU - Gabriel, Sherine E.
AU - Matteson, Eric L.
AU - Kvien, Tore K.
AU - Douglas, Karen
AU - Sandoo, Aamer
AU - Arts, Elke
AU - Wållberg-Jonsson, Solveig
AU - Innala, Lena
AU - Karpouzas, George
AU - Dessein, Patrick H.
AU - Tsang, Linda
AU - El-Gabalawy, Hani
AU - Hitchon, Carol
AU - Ramos, Virginia Pascual
AU - Yáñez, Irazä Contreras
AU - Sfkakis, Petros P.
AU - Zampeli, Evangelia
AU - Gonzalez-Gay, Miguel A.
AU - Corrales, Alfonso
AU - van de Laar, Mart
AU - Vonkeman, Harald E.
AU - Meek, Inger
AU - Semb, Anne Grete
N1 - Funding Information:
Funding this work was supported by a collaborative agreement for independent research from Eli Lilly, a grant from the national Institute of Arthritis and Musculoskeletal and Skin disease of the national Institutes of Health (grant number r01 Ar046849), and grants from the norwegian South East Health Authority (grant numbers 2013064, 2013010).the content is solely the responsibility of the authors and does not necessarily represent the official views of the national Institutes of Health.
Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - Objectives:
Patients with rheumatoid arthritis (RA) have an excess risk of
cardiovascular disease (CVD). We aimed to assess the impact of CVD risk
factors, including potential sex differences, and RA-specific variables on CVD
outcome in a large, international cohort of patients with RA.
Methods:
In 13 rheumatology centres, data on CVD risk factors and RA
characteristics were collected at baseline. CVD outcomes (myocardial
infarction, angina, revascularisation, stroke, peripheral vascular disease and
CVD death) were collected using standardised definitions.
Results:
5638 patients with RA and no prior CVD were included (mean age:
55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4)
years, 148 men and 241 women developed a CVD event (10-year cumulative incidence
20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors,
including increased blood pressure, higher total cholesterol and smoking
prevalence than women (all p<0.001). Among the traditional CVD risk factors,
smoking and hypertension had the highest population attributable risk (PAR)
overall and among both sexes, followed by total cholesterol. The PAR for
Disease Activity Score and for seropositivity were comparable in magnitude to
the PAR for lipids. A total of 70% of CVD events were attributable to all CVD
risk factors and RA characteristics combined (separately 49% CVD risk factors
and 30% RA characteristics).
Conclusions: In a
large, international cohort of patients with RA, 30% of CVD events were
attributable to RA characteristics. This finding indicates that RA
characteristics play an important role in efforts to reduce CVD risk among
patients with RA.
AB - Objectives:
Patients with rheumatoid arthritis (RA) have an excess risk of
cardiovascular disease (CVD). We aimed to assess the impact of CVD risk
factors, including potential sex differences, and RA-specific variables on CVD
outcome in a large, international cohort of patients with RA.
Methods:
In 13 rheumatology centres, data on CVD risk factors and RA
characteristics were collected at baseline. CVD outcomes (myocardial
infarction, angina, revascularisation, stroke, peripheral vascular disease and
CVD death) were collected using standardised definitions.
Results:
5638 patients with RA and no prior CVD were included (mean age:
55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4)
years, 148 men and 241 women developed a CVD event (10-year cumulative incidence
20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors,
including increased blood pressure, higher total cholesterol and smoking
prevalence than women (all p<0.001). Among the traditional CVD risk factors,
smoking and hypertension had the highest population attributable risk (PAR)
overall and among both sexes, followed by total cholesterol. The PAR for
Disease Activity Score and for seropositivity were comparable in magnitude to
the PAR for lipids. A total of 70% of CVD events were attributable to all CVD
risk factors and RA characteristics combined (separately 49% CVD risk factors
and 30% RA characteristics).
Conclusions: In a
large, international cohort of patients with RA, 30% of CVD events were
attributable to RA characteristics. This finding indicates that RA
characteristics play an important role in efforts to reduce CVD risk among
patients with RA.
KW - UT-Hybrid-D
KW - n/a OA procedure
UR - http://www.scopus.com/inward/record.url?scp=85038236789&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2017-211735
DO - 10.1136/annrheumdis-2017-211735
M3 - Article
C2 - 28877868
AN - SCOPUS:85038236789
SN - 0003-4967
VL - 77
SP - 48
EP - 54
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 1
ER -