Improved diagnostics by automated matching and enhancement in fluorescein angiography of the ocular fundus

Herke Jan Noordmans, Pieter Den Van Biesen, Rowland De Roode, Rudolf Verdaasdonk

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An interactive image matching program has been developed to help ophthalmologists in perceiving subtle differences between sequential images obtained during fluorescein angiography. In a pilot experiment, it appeared that the image matching program could effectively correct camera alignment errors. By offering simple tools like image overlay, blinking and image subtraction, differences between angiograms can be greatly enhanced and interpreted. It appeared that newly formed, leaking blood vessels could be detected at an earlier stage of the disease process using these tools. Treatment can be initiated right away, thereby preventing the patient from having additional visual loss. The matching program seems to improve the quality of fundus diagnostics but needs to be validated in future studies.

Original languageEnglish
Title of host publicationOphthalmic Technologies XVIII
Publication statusPublished - 26 May 2008
Externally publishedYes
EventOphthalmic Technologies XVIII 2008 - San Jose, United States
Duration: 19 Jan 200821 Jan 2008
Conference number: 18

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOphthalmic Technologies XVIII 2008
Country/TerritoryUnited States
CitySan Jose


  • Fundus imaging
  • Image registration
  • Ophthalmology
  • Retina images


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