Improved performance of aging human mesenchymal stromal cells for bone tissue engineering

Hugo André da Cunha Ribeiro Alves

Research output: ThesisPhD Thesis - Research UT, graduation UT

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In the last decades, an improvement in general life conditions has led to an increace in human life span but, concomitantly, also led to an increasing incidence of bone related disorders. A substancial effort has been placed in the development of new techologies to overcome current limitations of regenerative medicine. Human mesenchymal stromal cells (hMSCs) emerge as the golden standard for cell-based applications and are expected not only to increase current available therapies, but also, to allow the treatment of pathologies that, currently, have few accepted treatments or no cure. While hopes are high that many age-related degenerative diseases will be cured by stem cell therapy, there are still some hurdles that need to be addressed. Therefore, this thesis aims at improving hMSCs performance by using a diversified approach.
Original languageEnglish
Awarding Institution
  • University of Twente
  • van Blitterswijk, Clemens, Supervisor
  • de Boer, Jan, Advisor
Award date6 Jul 2011
Place of PublicationEnschede
Print ISBNs978-90-365-3218-1
Publication statusPublished - 6 Jul 2011


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