Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989-2006

L.N. van Steenbergen, M.A.G. Elferink, P. Krijnen, V.E.P.P. Lemmens, S. Siesling, H.J.T. Rutten, D.J. Richel, H.E. Karim-Kos, J.W.W. Coebergh

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: We described changes in treatment of colon cancer over time and the impact on survival in The Netherlands in the period 1989–2006.


Patients and methods: All 103 744 patients with invasive colon cancer during 1989–2006 in The Netherlands were included. Data were extracted from The Netherlands Cancer Registry. Trends in treatment over time were analysed and multivariable relative survival analysis was carried out.


Results: The administration of adjuvant chemotherapy in stage III patients <75 years increased from 19% in 1989–1993 to 79% in 2004–2006 and from 1% to 19% in stage III patients ≥75 years. Among stage IV patients, resection rates of the primary tumour decreased from 72% to 63%, while chemotherapy administration increased from 23% to 64% in those <75 years. Survival increased from 52% to 58% in males and from 55% to 58% among females. Stage III patients with adjuvant chemotherapy exhibited a relative excess risk of 0.4 (95% confidence interval 0.4–0.4) compared with those without. Among stage IV patients, resection of primary tumour, palliative chemotherapy, and metastasectomy were important prognostic factors.


Conclusions: There were substantial improvements in management and survival of colon cancer from 1989 to 2006. Stage III disease patients with colon cancer experienced the largest improvement in survival, most likely related to the increased administration of adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)2206-2212
JournalAnnals of oncology
Volume21
Issue number11
DOIs
Publication statusPublished - 2010

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Netherlands
Colonic Neoplasms
Survival
Population
Adjuvant Chemotherapy
Therapeutics
Metastasectomy
Drug Therapy
Neoplasms
Survival Analysis
Registries
Confidence Intervals

Keywords

  • IR-77370
  • METIS-271687

Cite this

van Steenbergen, L. N., Elferink, M. A. G., Krijnen, P., Lemmens, V. E. P. P., Siesling, S., Rutten, H. J. T., ... Coebergh, J. W. W. (2010). Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989-2006. Annals of oncology, 21(11), 2206-2212. https://doi.org/10.1093/annonc/mdq227
van Steenbergen, L.N. ; Elferink, M.A.G. ; Krijnen, P. ; Lemmens, V.E.P.P. ; Siesling, S. ; Rutten, H.J.T. ; Richel, D.J. ; Karim-Kos, H.E. ; Coebergh, J.W.W. / Improved survival of colon cancer due to improved treatment and detection : a nationwide population-based study in The Netherlands 1989-2006. In: Annals of oncology. 2010 ; Vol. 21, No. 11. pp. 2206-2212.
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title = "Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989-2006",
abstract = "Background: We described changes in treatment of colon cancer over time and the impact on survival in The Netherlands in the period 1989–2006.Patients and methods: All 103 744 patients with invasive colon cancer during 1989–2006 in The Netherlands were included. Data were extracted from The Netherlands Cancer Registry. Trends in treatment over time were analysed and multivariable relative survival analysis was carried out.Results: The administration of adjuvant chemotherapy in stage III patients <75 years increased from 19{\%} in 1989–1993 to 79{\%} in 2004–2006 and from 1{\%} to 19{\%} in stage III patients ≥75 years. Among stage IV patients, resection rates of the primary tumour decreased from 72{\%} to 63{\%}, while chemotherapy administration increased from 23{\%} to 64{\%} in those <75 years. Survival increased from 52{\%} to 58{\%} in males and from 55{\%} to 58{\%} among females. Stage III patients with adjuvant chemotherapy exhibited a relative excess risk of 0.4 (95{\%} confidence interval 0.4–0.4) compared with those without. Among stage IV patients, resection of primary tumour, palliative chemotherapy, and metastasectomy were important prognostic factors.Conclusions: There were substantial improvements in management and survival of colon cancer from 1989 to 2006. Stage III disease patients with colon cancer experienced the largest improvement in survival, most likely related to the increased administration of adjuvant chemotherapy.",
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author = "{van Steenbergen}, L.N. and M.A.G. Elferink and P. Krijnen and V.E.P.P. Lemmens and S. Siesling and H.J.T. Rutten and D.J. Richel and H.E. Karim-Kos and J.W.W. Coebergh",
note = "written on behalf of the Working Group Output of The Netherlands Cancer Registry",
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language = "English",
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van Steenbergen, LN, Elferink, MAG, Krijnen, P, Lemmens, VEPP, Siesling, S, Rutten, HJT, Richel, DJ, Karim-Kos, HE & Coebergh, JWW 2010, 'Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989-2006' Annals of oncology, vol. 21, no. 11, pp. 2206-2212. https://doi.org/10.1093/annonc/mdq227

Improved survival of colon cancer due to improved treatment and detection : a nationwide population-based study in The Netherlands 1989-2006. / van Steenbergen, L.N.; Elferink, M.A.G.; Krijnen, P.; Lemmens, V.E.P.P.; Siesling, S.; Rutten, H.J.T.; Richel, D.J.; Karim-Kos, H.E.; Coebergh, J.W.W.

In: Annals of oncology, Vol. 21, No. 11, 2010, p. 2206-2212.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Improved survival of colon cancer due to improved treatment and detection

T2 - a nationwide population-based study in The Netherlands 1989-2006

AU - van Steenbergen, L.N.

AU - Elferink, M.A.G.

AU - Krijnen, P.

AU - Lemmens, V.E.P.P.

AU - Siesling, S.

AU - Rutten, H.J.T.

AU - Richel, D.J.

AU - Karim-Kos, H.E.

AU - Coebergh, J.W.W.

N1 - written on behalf of the Working Group Output of The Netherlands Cancer Registry

PY - 2010

Y1 - 2010

N2 - Background: We described changes in treatment of colon cancer over time and the impact on survival in The Netherlands in the period 1989–2006.Patients and methods: All 103 744 patients with invasive colon cancer during 1989–2006 in The Netherlands were included. Data were extracted from The Netherlands Cancer Registry. Trends in treatment over time were analysed and multivariable relative survival analysis was carried out.Results: The administration of adjuvant chemotherapy in stage III patients <75 years increased from 19% in 1989–1993 to 79% in 2004–2006 and from 1% to 19% in stage III patients ≥75 years. Among stage IV patients, resection rates of the primary tumour decreased from 72% to 63%, while chemotherapy administration increased from 23% to 64% in those <75 years. Survival increased from 52% to 58% in males and from 55% to 58% among females. Stage III patients with adjuvant chemotherapy exhibited a relative excess risk of 0.4 (95% confidence interval 0.4–0.4) compared with those without. Among stage IV patients, resection of primary tumour, palliative chemotherapy, and metastasectomy were important prognostic factors.Conclusions: There were substantial improvements in management and survival of colon cancer from 1989 to 2006. Stage III disease patients with colon cancer experienced the largest improvement in survival, most likely related to the increased administration of adjuvant chemotherapy.

AB - Background: We described changes in treatment of colon cancer over time and the impact on survival in The Netherlands in the period 1989–2006.Patients and methods: All 103 744 patients with invasive colon cancer during 1989–2006 in The Netherlands were included. Data were extracted from The Netherlands Cancer Registry. Trends in treatment over time were analysed and multivariable relative survival analysis was carried out.Results: The administration of adjuvant chemotherapy in stage III patients <75 years increased from 19% in 1989–1993 to 79% in 2004–2006 and from 1% to 19% in stage III patients ≥75 years. Among stage IV patients, resection rates of the primary tumour decreased from 72% to 63%, while chemotherapy administration increased from 23% to 64% in those <75 years. Survival increased from 52% to 58% in males and from 55% to 58% among females. Stage III patients with adjuvant chemotherapy exhibited a relative excess risk of 0.4 (95% confidence interval 0.4–0.4) compared with those without. Among stage IV patients, resection of primary tumour, palliative chemotherapy, and metastasectomy were important prognostic factors.Conclusions: There were substantial improvements in management and survival of colon cancer from 1989 to 2006. Stage III disease patients with colon cancer experienced the largest improvement in survival, most likely related to the increased administration of adjuvant chemotherapy.

KW - IR-77370

KW - METIS-271687

U2 - 10.1093/annonc/mdq227

DO - 10.1093/annonc/mdq227

M3 - Article

VL - 21

SP - 2206

EP - 2212

JO - Annals of oncology

JF - Annals of oncology

SN - 0923-7534

IS - 11

ER -