Improvement of sodium status to optimize the efficacy of renin-angiotensin system blockade

Gozewijn D. Laverman; Gerjan Navis

doi:10.1007/s11906-011-0234-7

Improvement of sodium status to optimize the efficacy of renin-angiotensin system blockade

Gozewijn D. Laverman, Gerjan Navis^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

2 Citations (Scopus)

Abstract

Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.

Original language	English
Pages (from-to)	397-399
Number of pages	3
Journal	Current Hypertension Reports
Volume	13
Issue number	6
DOIs	https://doi.org/10.1007/s11906-011-0234-7
Publication status	Published - Dec 2011
Externally published	Yes

Keywords

24-hour urine collection
Blood pressure
Chronic kidney disease
Extracellular volume
Hypertension
N-terminal pro-brain natriuretic peptide
NT-proBNP
RAAS blockade
Renin-angiotensin system
Renin-angiotensin-aldosterone system
Renoprotection
Sodium
Therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11906-011-0234-7Licence: CC BY-NC

ArticleFinal published version, 69.2 KBLicence: CC BY-NC

Cite this

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title = "Improvement of sodium status to optimize the efficacy of renin-angiotensin system blockade",

abstract = "Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.",

keywords = "24-hour urine collection, Blood pressure, Chronic kidney disease, Extracellular volume, Hypertension, N-terminal pro-brain natriuretic peptide, NT-proBNP, RAAS blockade, Renin-angiotensin system, Renin-angiotensin-aldosterone system, Renoprotection, Sodium, Therapy",

author = "Laverman, {Gozewijn D.} and Gerjan Navis",

year = "2011",

month = dec,

doi = "10.1007/s11906-011-0234-7",

language = "English",

volume = "13",

pages = "397--399",

journal = "Current Hypertension Reports",

issn = "1522-6417",

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T1 - Improvement of sodium status to optimize the efficacy of renin-angiotensin system blockade

AU - Laverman, Gozewijn D.

AU - Navis, Gerjan

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N2 - Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.

AB - Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.

KW - 24-hour urine collection

KW - Blood pressure

KW - Chronic kidney disease

KW - Extracellular volume

KW - Hypertension

KW - N-terminal pro-brain natriuretic peptide

KW - NT-proBNP

KW - RAAS blockade

KW - Renin-angiotensin system

KW - Renin-angiotensin-aldosterone system

KW - Renoprotection

KW - Sodium

KW - Therapy

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U2 - 10.1007/s11906-011-0234-7

DO - 10.1007/s11906-011-0234-7

M3 - Review article

C2 - PMC3212696

SN - 1522-6417

VL - 13

SP - 397

EP - 399

JO - Current Hypertension Reports

JF - Current Hypertension Reports

IS - 6

ER -

Improvement of sodium status to optimize the efficacy of renin-angiotensin system blockade

Abstract

Keywords

UN SDGs

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