Improving circulating tumor cell detection from diagnostic leukapheresis material: Getting the most out of it

Research output: ThesisPhD Thesis - Research UT, graduation UT

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Abstract

Enriching Circulating Tumor Cells (CTCs) from Diagnostic LeukApheresis (DLA) samples via optimized magnetic flow separation allows for processing larger aliquots of DLA while using less reagents.
In this way, a much larger number of CTCs can be obtained, with which the diagnoses and treatment of cancer patients can be improved.
Fluorescence images of the enriched cells can be efficiently segmented using StarDist and the detected cells can be individually isolated using a magnetic microneedle.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Terstappen, Leon, Supervisor
  • Coumans, Frank Annie Willy, Co-Supervisor
Award date8 Dec 2023
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-5908-9
Electronic ISBNs978-90-365-5909-6
DOIs
Publication statusPublished - 8 Dec 2023

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