Improving circulating tumor cell detection from diagnostic leukapheresis material: Getting the most out of it

Michiel Stevens

doi:10.3990/1.9789036559096

Improving circulating tumor cell detection from diagnostic leukapheresis material: Getting the most out of it

Michiel Stevens

Medical Cell Biophysics

Research output: Thesis › PhD Thesis - Research UT, graduation UT

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Abstract

Enriching Circulating Tumor Cells (CTCs) from Diagnostic LeukApheresis (DLA) samples via optimized magnetic flow separation allows for processing larger aliquots of DLA while using less reagents.
In this way, a much larger number of CTCs can be obtained, with which the diagnoses and treatment of cancer patients can be improved.
Fluorescence images of the enriched cells can be efficiently segmented using StarDist and the detected cells can be individually isolated using a magnetic microneedle.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Twente
Supervisors/Advisors	Terstappen, Leon, Supervisor Coumans, Frank Annie Willy, Co-Supervisor
Award date	8 Dec 2023
Place of Publication	Enschede
Publisher	University of Twente
Print ISBNs	978-90-365-5908-9
Electronic ISBNs	978-90-365-5909-6
DOIs	https://doi.org/10.3990/1.9789036559096
Publication status	Published - 8 Dec 2023

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PhD-thesis Michiel StevensFinal published version, 18.3 MB

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title = "Improving circulating tumor cell detection from diagnostic leukapheresis material: Getting the most out of it",

abstract = "Enriching Circulating Tumor Cells (CTCs) from Diagnostic LeukApheresis (DLA) samples via optimized magnetic flow separation allows for processing larger aliquots of DLA while using less reagents.In this way, a much larger number of CTCs can be obtained, with which the diagnoses and treatment of cancer patients can be improved. Fluorescence images of the enriched cells can be efficiently segmented using StarDist and the detected cells can be individually isolated using a magnetic microneedle.",

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AB - Enriching Circulating Tumor Cells (CTCs) from Diagnostic LeukApheresis (DLA) samples via optimized magnetic flow separation allows for processing larger aliquots of DLA while using less reagents.In this way, a much larger number of CTCs can be obtained, with which the diagnoses and treatment of cancer patients can be improved. Fluorescence images of the enriched cells can be efficiently segmented using StarDist and the detected cells can be individually isolated using a magnetic microneedle.

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M3 - PhD Thesis - Research UT, graduation UT

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Improving circulating tumor cell detection from diagnostic leukapheresis material: Getting the most out of it

Abstract

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