Improving mixing in microbioreactors

X. Li, G. van der Steen, G.W.K. Dedum, L.A.M. van der Wielen, M. van Leeuwen, W.M. van Gulik, J.J. Heijnen, E.E. Krommenhoek, Johannes G.E. Gardeniers, Albert van den Berg, M. Ottens

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)


This paper describes a possible active mixing method for a 30 mu l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior. (C) 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)3036-3046
Number of pages11
JournalChemical engineering science
Issue number11
Publication statusPublished - Jun 2008


  • METIS-247851
  • EWI-13018
  • IR-62378


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