Improving mixing in microbioreactors

X. Li; G. van der Steen; G.W.K. Dedum; L.A.M. van der Wielen; M. van Leeuwen; W.M. van Gulik; J.J. Heijnen; E.E. Krommenhoek; Johannes G.E. Gardeniers; Albert van den Berg; M. Ottens

doi:10.1016/j.ces.2008.02.036

Improving mixing in microbioreactors

X. Li, G. van der Steen, G.W.K. Dedum, L.A.M. van der Wielen, M. van Leeuwen, W.M. van Gulik, J.J. Heijnen, E.E. Krommenhoek, Johannes G.E. Gardeniers, Albert van den Berg, M. Ottens

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Abstract

This paper describes a possible active mixing method for a 30 mu l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior. (C) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3036-3046
Number of pages	11
Journal	Chemical engineering science
Volume	63
Issue number	11
DOIs	https://doi.org/10.1016/j.ces.2008.02.036
Publication status	Published - Jun 2008

Keywords

METIS-247851
EWI-13018
IR-62378

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10.1016/j.ces.2008.02.036

http://eprints.eemcs.utwente.nl/secure2/13018/01/Krommenhoek_-_Improving_mixing....pdf

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title = "Improving mixing in microbioreactors",

abstract = "This paper describes a possible active mixing method for a 30 mu l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior. (C) 2008 Elsevier Ltd. All rights reserved.",

keywords = "METIS-247851, EWI-13018, IR-62378",

author = "X. Li and {van der Steen}, G. and G.W.K. Dedum and {van der Wielen}, L.A.M. and {van Leeuwen}, M. and {van Gulik}, W.M. and J.J. Heijnen and E.E. Krommenhoek and Gardeniers, {Johannes G.E.} and {van den Berg}, Albert and M. Ottens",

note = "http://dx.doi.org/10.1016/j.ces.2008.02.036 ",

year = "2008",

month = jun,

doi = "10.1016/j.ces.2008.02.036",

language = "English",

volume = "63",

pages = "3036--3046",

journal = "Chemical engineering science",

issn = "0009-2509",

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TY - JOUR

T1 - Improving mixing in microbioreactors

AU - Li, X.

AU - van der Steen, G.

AU - Dedum, G.W.K.

AU - van der Wielen, L.A.M.

AU - van Leeuwen, M.

AU - van Gulik, W.M.

AU - Heijnen, J.J.

AU - Krommenhoek, E.E.

AU - Gardeniers, Johannes G.E.

AU - van den Berg, Albert

AU - Ottens, M.

N1 - http://dx.doi.org/10.1016/j.ces.2008.02.036

PY - 2008/6

Y1 - 2008/6

N2 - This paper describes a possible active mixing method for a 30 mu l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior. (C) 2008 Elsevier Ltd. All rights reserved.

AB - This paper describes a possible active mixing method for a 30 mu l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior. (C) 2008 Elsevier Ltd. All rights reserved.

KW - METIS-247851

KW - EWI-13018

KW - IR-62378

U2 - 10.1016/j.ces.2008.02.036

DO - 10.1016/j.ces.2008.02.036

M3 - Article

SN - 0009-2509

VL - 63

SP - 3036

EP - 3046

JO - Chemical engineering science

JF - Chemical engineering science

IS - 11

ER -

Improving mixing in microbioreactors

Abstract

Keywords

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