In control: methodological and clinical aspects of cerebral autoregulation and haemodynamics

Aisha van den Abeelen

Research output: ThesisPhD Thesis - Research external, graduation externalAcademic

68 Downloads (Pure)

Abstract

Cerebral autoregulation (CA) is a key mechanism to protect the brain against excessive fluctuations in blood pressure (BP) and maintain cerebral blood flow. Analysing the relationship between spontaneous BP and cerebral blood flow velocity (CBFV) using transfer function analysis is a widely used technique to quantify CA in a non-invasive way. The objective of this review was to provide an overview of transfer function techniques used in the assessment of CA. For this review, 113 publications were included. This literature showed that there is no gold standard for the execution and implementation of the transfer function. There is a high diversity in settings and criteria used for transfer function analysis. Notable is also the high number of studies which report little on the settings. This disparity makes it difficult to replicate or compare the results of the different studies and further hinders the opportunity to make a distinction between intact and impaired CA in different patient groups. More research on the effects of different implementation techniques on outcomes for CA and optimization of the transfer function analysis is urgently needed. Furthermore, the results of this review show that international guidelines should be created to inform the minimal description of the applied technique and the interpretation of transfer function outcomes in scientific research.
Original languageUndefined
Awarding Institution
  • Radboud University Nijmegen
Supervisors/Advisors
  • Slump, Cornelis H., Supervisor
  • Olde Rikkert, M.G.M., Supervisor
  • Claassen, J.A.H.R., Advisor
  • Lagro, J., Advisor
Thesis sponsors
Award date3 Dec 2014
Place of PublicationNijmegen
Publisher
Print ISBNs978-94-6284-006-5
Publication statusPublished - 3 Dec 2014

Keywords

  • transfer function analysis
  • METIS-309863
  • sepsis
  • hypotensive syndroms
  • cerebral autoregulation
  • Alzheimer's disease
  • EWI-25648
  • IR-93881

Cite this

van den Abeelen, Aisha. / In control: methodological and clinical aspects of cerebral autoregulation and haemodynamics. Nijmegen : Donders Instituut, 2014. 325 p.
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title = "In control: methodological and clinical aspects of cerebral autoregulation and haemodynamics",
abstract = "Cerebral autoregulation (CA) is a key mechanism to protect the brain against excessive fluctuations in blood pressure (BP) and maintain cerebral blood flow. Analysing the relationship between spontaneous BP and cerebral blood flow velocity (CBFV) using transfer function analysis is a widely used technique to quantify CA in a non-invasive way. The objective of this review was to provide an overview of transfer function techniques used in the assessment of CA. For this review, 113 publications were included. This literature showed that there is no gold standard for the execution and implementation of the transfer function. There is a high diversity in settings and criteria used for transfer function analysis. Notable is also the high number of studies which report little on the settings. This disparity makes it difficult to replicate or compare the results of the different studies and further hinders the opportunity to make a distinction between intact and impaired CA in different patient groups. More research on the effects of different implementation techniques on outcomes for CA and optimization of the transfer function analysis is urgently needed. Furthermore, the results of this review show that international guidelines should be created to inform the minimal description of the applied technique and the interpretation of transfer function outcomes in scientific research.",
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van den Abeelen, A 2014, 'In control: methodological and clinical aspects of cerebral autoregulation and haemodynamics', Radboud University Nijmegen, Nijmegen.

In control: methodological and clinical aspects of cerebral autoregulation and haemodynamics. / van den Abeelen, Aisha.

Nijmegen : Donders Instituut, 2014. 325 p.

Research output: ThesisPhD Thesis - Research external, graduation externalAcademic

TY - THES

T1 - In control: methodological and clinical aspects of cerebral autoregulation and haemodynamics

AU - van den Abeelen, Aisha

N1 - eemcs-eprint-25648

PY - 2014/12/3

Y1 - 2014/12/3

N2 - Cerebral autoregulation (CA) is a key mechanism to protect the brain against excessive fluctuations in blood pressure (BP) and maintain cerebral blood flow. Analysing the relationship between spontaneous BP and cerebral blood flow velocity (CBFV) using transfer function analysis is a widely used technique to quantify CA in a non-invasive way. The objective of this review was to provide an overview of transfer function techniques used in the assessment of CA. For this review, 113 publications were included. This literature showed that there is no gold standard for the execution and implementation of the transfer function. There is a high diversity in settings and criteria used for transfer function analysis. Notable is also the high number of studies which report little on the settings. This disparity makes it difficult to replicate or compare the results of the different studies and further hinders the opportunity to make a distinction between intact and impaired CA in different patient groups. More research on the effects of different implementation techniques on outcomes for CA and optimization of the transfer function analysis is urgently needed. Furthermore, the results of this review show that international guidelines should be created to inform the minimal description of the applied technique and the interpretation of transfer function outcomes in scientific research.

AB - Cerebral autoregulation (CA) is a key mechanism to protect the brain against excessive fluctuations in blood pressure (BP) and maintain cerebral blood flow. Analysing the relationship between spontaneous BP and cerebral blood flow velocity (CBFV) using transfer function analysis is a widely used technique to quantify CA in a non-invasive way. The objective of this review was to provide an overview of transfer function techniques used in the assessment of CA. For this review, 113 publications were included. This literature showed that there is no gold standard for the execution and implementation of the transfer function. There is a high diversity in settings and criteria used for transfer function analysis. Notable is also the high number of studies which report little on the settings. This disparity makes it difficult to replicate or compare the results of the different studies and further hinders the opportunity to make a distinction between intact and impaired CA in different patient groups. More research on the effects of different implementation techniques on outcomes for CA and optimization of the transfer function analysis is urgently needed. Furthermore, the results of this review show that international guidelines should be created to inform the minimal description of the applied technique and the interpretation of transfer function outcomes in scientific research.

KW - transfer function analysis

KW - METIS-309863

KW - sepsis

KW - hypotensive syndroms

KW - cerebral autoregulation

KW - Alzheimer's disease

KW - EWI-25648

KW - IR-93881

M3 - PhD Thesis - Research external, graduation external

SN - 978-94-6284-006-5

PB - Donders Instituut

CY - Nijmegen

ER -

van den Abeelen A. In control: methodological and clinical aspects of cerebral autoregulation and haemodynamics. Nijmegen: Donders Instituut, 2014. 325 p.