TY - JOUR
T1 - In-line Sensing of Sodium Ascorbate Using a Poly(ferrocenylsilane)-coated Microfluidic Device
AU - Kieviet, Bernard D.
AU - Dos Ramos, Lionel
AU - Hempenius, Mark A.
AU - Duvigneau, Joost
AU - Schön, Peter M.
AU - Vancso, G. Julius
PY - 2016/8/26
Y1 - 2016/8/26
N2 - Poly(ferrocenylsilane) (PFS) is a redox-active polymer that can be utilized in a variety of applications, such as sensing, nanoparticle foundries or dual-responsive hydrogels, due to the fact that it can be partially or completely oxidized, reversibly, by (electro)chemical means. In this research, PFS is tethered to a cysteamine-modified gold-coated microchannel electrode via amine alkylation, following a recent published procedure for conventional macro-sized electrodes. The PFS-coated microfluidic device is successfully employed as an electrochemical sensor for sodium l-ascorbate, or vitamin C, with a detection limit of 0.5 mM in aqueous solution. The fabrication of the device, that comprises gold-coated electrodes of micrometers in width, is discussed, as well as the static and in-line detection of sodium l-ascorbate. The analyte concentration is sensed through an electrocatalytic process in both static and in-line cases, by cyclic voltammetry and amperometry, respectively. The findings presented in this work open novel opportunities for local surface modification of chip-integrated gold electrodes by redox-responsive polymers used, e.g., as electrochemical sensors.
AB - Poly(ferrocenylsilane) (PFS) is a redox-active polymer that can be utilized in a variety of applications, such as sensing, nanoparticle foundries or dual-responsive hydrogels, due to the fact that it can be partially or completely oxidized, reversibly, by (electro)chemical means. In this research, PFS is tethered to a cysteamine-modified gold-coated microchannel electrode via amine alkylation, following a recent published procedure for conventional macro-sized electrodes. The PFS-coated microfluidic device is successfully employed as an electrochemical sensor for sodium l-ascorbate, or vitamin C, with a detection limit of 0.5 mM in aqueous solution. The fabrication of the device, that comprises gold-coated electrodes of micrometers in width, is discussed, as well as the static and in-line detection of sodium l-ascorbate. The analyte concentration is sensed through an electrocatalytic process in both static and in-line cases, by cyclic voltammetry and amperometry, respectively. The findings presented in this work open novel opportunities for local surface modification of chip-integrated gold electrodes by redox-responsive polymers used, e.g., as electrochemical sensors.
KW - 2023 OA procedure
U2 - 10.1016/j.eurpolymj.2016.08.026
DO - 10.1016/j.eurpolymj.2016.08.026
M3 - Article
SN - 0014-3057
VL - 83
SP - 337
EP - 343
JO - European polymer journal
JF - European polymer journal
ER -