A pilot evaluation is reported of a reminiscence program aimed at increasing personal meaning. Fifty-seven older persons completed both a sentence completion questionnaire measuring personal meaning and a depression scale administered before and after the program. In comparison to a group from a representative survey that was matched on life contexts, the personal meaning profile of the intervention group was more negative and more focused on self. Hence, a group with impoverished meaning was participating in the program. After the intervention, the personal meaning profile was more positive, in particular with regard to self-evaluations and evaluations of social relations. The group that improved most on depression also improved most on personal meaning. Further research on the program is warranted.