In situ surface-enhanced raman spectroelectrochemical analysis system with a hemin modified nanostructured gold surface

Tao Yuan, Loan Le Thi Ngoc, Jan William van Nieuwkasteele, Mathieu Odijk, Albert van den Berg, Hjalmar Permentier, Rainer Bischoff, Edwin Carlen

Research output: Contribution to journalArticle

  • 12 Citations

Abstract

An integrated surface-enhanced Raman scattering (SERS) spectroelectrochemical (SEC) analysis system is presented that combines a small volume microfluidic sample chamber (<100 mu L) with a compact three-electrode configuration for in situ surface-enhanced Raman spectroelectrochemistry. The SEC system includes a nanostructured Au surface that serves dual roles as the electrochemical working electrode (WE) and SERS substrate, a microfabricated Pt counter electrode (CE), and an external Ag/AgCl reference electrode (RE). The nanostructured Au WE enables highly sensitive in situ SERS spectroscopy through large and reproducible SERS enhancements, which eliminates the need for resonant wavelength matching of the laser excitation source with the electronic absorption of the target molecule. The new SEC analysis system has the merits of wide applicability to target molecules, small sample volume, and a low detection limit. We demonstrate in situ SERS spectroelectrochemistry measurements of the metalloporphyrin hemin showing shifts of the iron oxidation marker band nu(4) with the nanostructured Au working electrode under precise potential control
LanguageUndefined
Pages2588-2592
Number of pages5
JournalAnalytical chemistry
Volume87
Issue number5
DOIs
StatePublished - 3 Mar 2015

Keywords

  • EWI-26002
  • IR-95870
  • METIS-312596

Cite this

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title = "In situ surface-enhanced raman spectroelectrochemical analysis system with a hemin modified nanostructured gold surface",
abstract = "An integrated surface-enhanced Raman scattering (SERS) spectroelectrochemical (SEC) analysis system is presented that combines a small volume microfluidic sample chamber (<100 mu L) with a compact three-electrode configuration for in situ surface-enhanced Raman spectroelectrochemistry. The SEC system includes a nanostructured Au surface that serves dual roles as the electrochemical working electrode (WE) and SERS substrate, a microfabricated Pt counter electrode (CE), and an external Ag/AgCl reference electrode (RE). The nanostructured Au WE enables highly sensitive in situ SERS spectroscopy through large and reproducible SERS enhancements, which eliminates the need for resonant wavelength matching of the laser excitation source with the electronic absorption of the target molecule. The new SEC analysis system has the merits of wide applicability to target molecules, small sample volume, and a low detection limit. We demonstrate in situ SERS spectroelectrochemistry measurements of the metalloporphyrin hemin showing shifts of the iron oxidation marker band nu(4) with the nanostructured Au working electrode under precise potential control",
keywords = "EWI-26002, IR-95870, METIS-312596",
author = "Tao Yuan and {Le Thi Ngoc}, Loan and {van Nieuwkasteele}, {Jan William} and Mathieu Odijk and {van den Berg}, Albert and Hjalmar Permentier and Rainer Bischoff and Edwin Carlen",
note = "eemcs-eprint-26002",
year = "2015",
month = "3",
day = "3",
doi = "10.1021/ac504136j",
language = "Undefined",
volume = "87",
pages = "2588--2592",
journal = "Analytical chemistry",
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In situ surface-enhanced raman spectroelectrochemical analysis system with a hemin modified nanostructured gold surface. / Yuan, Tao; Le Thi Ngoc, Loan; van Nieuwkasteele, Jan William; Odijk, Mathieu; van den Berg, Albert; Permentier, Hjalmar; Bischoff, Rainer; Carlen, Edwin.

In: Analytical chemistry, Vol. 87, No. 5, 03.03.2015, p. 2588-2592.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In situ surface-enhanced raman spectroelectrochemical analysis system with a hemin modified nanostructured gold surface

AU - Yuan,Tao

AU - Le Thi Ngoc,Loan

AU - van Nieuwkasteele,Jan William

AU - Odijk,Mathieu

AU - van den Berg,Albert

AU - Permentier,Hjalmar

AU - Bischoff,Rainer

AU - Carlen,Edwin

N1 - eemcs-eprint-26002

PY - 2015/3/3

Y1 - 2015/3/3

N2 - An integrated surface-enhanced Raman scattering (SERS) spectroelectrochemical (SEC) analysis system is presented that combines a small volume microfluidic sample chamber (<100 mu L) with a compact three-electrode configuration for in situ surface-enhanced Raman spectroelectrochemistry. The SEC system includes a nanostructured Au surface that serves dual roles as the electrochemical working electrode (WE) and SERS substrate, a microfabricated Pt counter electrode (CE), and an external Ag/AgCl reference electrode (RE). The nanostructured Au WE enables highly sensitive in situ SERS spectroscopy through large and reproducible SERS enhancements, which eliminates the need for resonant wavelength matching of the laser excitation source with the electronic absorption of the target molecule. The new SEC analysis system has the merits of wide applicability to target molecules, small sample volume, and a low detection limit. We demonstrate in situ SERS spectroelectrochemistry measurements of the metalloporphyrin hemin showing shifts of the iron oxidation marker band nu(4) with the nanostructured Au working electrode under precise potential control

AB - An integrated surface-enhanced Raman scattering (SERS) spectroelectrochemical (SEC) analysis system is presented that combines a small volume microfluidic sample chamber (<100 mu L) with a compact three-electrode configuration for in situ surface-enhanced Raman spectroelectrochemistry. The SEC system includes a nanostructured Au surface that serves dual roles as the electrochemical working electrode (WE) and SERS substrate, a microfabricated Pt counter electrode (CE), and an external Ag/AgCl reference electrode (RE). The nanostructured Au WE enables highly sensitive in situ SERS spectroscopy through large and reproducible SERS enhancements, which eliminates the need for resonant wavelength matching of the laser excitation source with the electronic absorption of the target molecule. The new SEC analysis system has the merits of wide applicability to target molecules, small sample volume, and a low detection limit. We demonstrate in situ SERS spectroelectrochemistry measurements of the metalloporphyrin hemin showing shifts of the iron oxidation marker band nu(4) with the nanostructured Au working electrode under precise potential control

KW - EWI-26002

KW - IR-95870

KW - METIS-312596

U2 - 10.1021/ac504136j

DO - 10.1021/ac504136j

M3 - Article

VL - 87

SP - 2588

EP - 2592

JO - Analytical chemistry

T2 - Analytical chemistry

JF - Analytical chemistry

SN - 0003-2700

IS - 5

ER -