Two experiments tested the hypothesis that a positive mood can increase attendance to, and systematic processing of, threatening health information, particularly when the information is self-relevant. In Study 1, a positive mood increased differentiation between strong and weak arguments in a threatening health message about RSI only for participants who had received false feedback regarding their high vulnerability to RSI. Mood had no effects under conditions of low vulnerability. In Study 2, a positive mood speeded up responses to self-threatening words—compared with neutral words—for smokers who had just read a threatening health message about smoking. The authors conclude that fostering a positive mood may promote attendance to and systematic processing of information that threatens the self, and hence contribute to the success of health campaigns targeted at individuals who are vulnerable to specific health risks.