In Vitro and In Vivo Characterization of Biodegradable Reactive Isocyanate-Terminated Three-Armed- and Hyperbranched Block Copolymeric Tissue Adhesives

Agnieszka I. Bochynska, Gerjon Hannink*, Jan J. Rongen, Dirk W. Grijpma, Pieter Buma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Tissue adhesives are an attractive class of biomaterials, which can serve as a treatment for meniscus tears. In this study, physicochemical and adhesive properties of novel biodegradable three-armed- and hyperbranched block copolymeric adhesives are evaluated. Additionally, their degradation in vitro and in vivo, and the tissue reaction after subcutaneous injection in rats are assessed. The developed adhesives have sufficient adhesive strength to meniscus tissue after curing (66–88 kPa). Networks based on the three-armed adhesive have tensile properties that are in the same range as human meniscus. After 26 weeks, networks based on the hyperbranched adhesive show a faster mass loss (25.4%) compared to networks prepared from the three-armed ones (5.5%). Both adhesives induce an inflammatory reaction, however, no necrosis and only initial toxic effects on peripheral tissues are observed. The proposed materials are suitable candidates for the use as resorbable tissue adhesives for meniscus repair.

Original languageEnglish
Article number1700125
JournalMacromolecular bioscience
Volume17
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • biocompatibility
  • biodegradable
  • block-copolymer
  • hyperbranched polymer
  • three-armed polymer
  • tissue adhesive

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