In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

Astrid M. Hoving, Jason Voorneveld, Evelien E. De Vries, Erik Groot Jebbink, Michel Versluis, Johan G. Bosch, Nico de Jong, Julia Mikhal, Gert J. De Borst, Cornelis H. Slump

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

1 Citation (Scopus)
9 Downloads (Pure)

Abstract

Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.

Original languageEnglish
Title of host publicationMedical Imaging 2018
Subtitle of host publicationUltrasonic Imaging and Tomography
EditorsNeb Duric, Brett C. Byram
PublisherSPIE
Pages5
Volume10580
ISBN (Electronic)9781510616493
ISBN (Print)978-1-5106-1649-3
DOIs
Publication statusPublished - 6 Mar 2018
EventSPIE Medical Imaging 2018: Ultrasonic Imaging and Tomography - Marriott Marquis Houston, Houston, United States
Duration: 13 Feb 201815 Feb 2018

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume10580

Conference

ConferenceSPIE Medical Imaging 2018
CountryUnited States
CityHouston
Period13/02/1815/02/18

Fingerprint

Stents
Rheology
particle image velocimetry
arteries
Carotid Arteries
Velocity measurement
Ultrasonics
correlation coefficients
Microbubbles
Silicones
Contrast Media
Theoretical Models
silicones
Singular value decomposition
In Vitro Techniques
laminar flow
Laminar flow
blood
Numerical models
acquisition

Keywords

  • Carotid artery
  • Contrast-enhanced
  • High-frame-rate
  • Particle image velocimetry
  • Ultrasound

Cite this

Hoving, A. M., Voorneveld, J., De Vries, E. E., Groot Jebbink, E., Versluis, M., Bosch, J. G., ... Slump, C. H. (2018). In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. In N. Duric, & B. C. Byram (Eds.), Medical Imaging 2018: Ultrasonic Imaging and Tomography (Vol. 10580, pp. 5). [105800A] (Proceedings of SPIE; Vol. 10580). SPIE. https://doi.org/10.1117/12.2293669
Hoving, Astrid M. ; Voorneveld, Jason ; De Vries, Evelien E. ; Groot Jebbink, Erik ; Versluis, Michel ; Bosch, Johan G. ; de Jong, Nico ; Mikhal, Julia ; De Borst, Gert J. ; Slump, Cornelis H. / In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. Medical Imaging 2018: Ultrasonic Imaging and Tomography. editor / Neb Duric ; Brett C. Byram. Vol. 10580 SPIE, 2018. pp. 5 (Proceedings of SPIE).
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abstract = "Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.",
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Hoving, AM, Voorneveld, J, De Vries, EE, Groot Jebbink, E, Versluis, M, Bosch, JG, de Jong, N, Mikhal, J, De Borst, GJ & Slump, CH 2018, In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. in N Duric & BC Byram (eds), Medical Imaging 2018: Ultrasonic Imaging and Tomography. vol. 10580, 105800A, Proceedings of SPIE, vol. 10580, SPIE, pp. 5, SPIE Medical Imaging 2018, Houston, United States, 13/02/18. https://doi.org/10.1117/12.2293669

In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. / Hoving, Astrid M.; Voorneveld, Jason; De Vries, Evelien E.; Groot Jebbink, Erik; Versluis, Michel; Bosch, Johan G.; de Jong, Nico; Mikhal, Julia; De Borst, Gert J.; Slump, Cornelis H.

Medical Imaging 2018: Ultrasonic Imaging and Tomography. ed. / Neb Duric; Brett C. Byram. Vol. 10580 SPIE, 2018. p. 5 105800A (Proceedings of SPIE; Vol. 10580).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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T1 - In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

AU - Hoving, Astrid M.

AU - Voorneveld, Jason

AU - De Vries, Evelien E.

AU - Groot Jebbink, Erik

AU - Versluis, Michel

AU - Bosch, Johan G.

AU - de Jong, Nico

AU - Mikhal, Julia

AU - De Borst, Gert J.

AU - Slump, Cornelis H.

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Y1 - 2018/3/6

N2 - Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.

AB - Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.

KW - Carotid artery

KW - Contrast-enhanced

KW - High-frame-rate

KW - Particle image velocimetry

KW - Ultrasound

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Hoving AM, Voorneveld J, De Vries EE, Groot Jebbink E, Versluis M, Bosch JG et al. In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. In Duric N, Byram BC, editors, Medical Imaging 2018: Ultrasonic Imaging and Tomography. Vol. 10580. SPIE. 2018. p. 5. 105800A. (Proceedings of SPIE). https://doi.org/10.1117/12.2293669