In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

Astrid M. Hoving; Jason Voorneveld; Evelien E. De Vries; Erik Groot Jebbink; Michel Versluis; Johan G. Bosch; Nico de Jong; Julia Mikhal; Gert J. De Borst; Cornelis H. Slump

doi:10.1117/12.2293669

In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

Astrid M. Hoving, Jason Voorneveld, Evelien E. De Vries, Erik Groot Jebbink, Michel Versluis, Johan G. Bosch, Nico de Jong, Julia Mikhal, Gert J. De Borst, Cornelis H. Slump

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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Abstract

Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.

Original language	English
Title of host publication	Medical Imaging 2018
Subtitle of host publication	Ultrasonic Imaging and Tomography
Editors	Neb Duric, Brett C. Byram
Publisher	SPIE
Pages	5
Volume	10580
ISBN (Electronic)	9781510616493
ISBN (Print)	978-1-5106-1649-3
DOIs	https://doi.org/10.1117/12.2293669
Publication status	Published - 6 Mar 2018
Event	SPIE Medical Imaging 2018: Ultrasonic Imaging and Tomography - Marriott Marquis Houston, Houston, United States Duration: 10 Feb 2018 → 15 Feb 2018

Publication series

Name	Proceedings of SPIE
Publisher	SPIE
Volume	10580

Conference

Conference	SPIE Medical Imaging 2018
Country/Territory	United States
City	Houston
Period	10/02/18 → 15/02/18

Keywords

Carotid artery
Contrast-enhanced
High-frame-rate
Particle image velocimetry
Ultrasound

Access to Document

10.1117/12.2293669

Cite this

Hoving, A. M., Voorneveld, J., De Vries, E. E., Groot Jebbink, E., Versluis, M., Bosch, J. G., de Jong, N., Mikhal, J., De Borst, G. J., & Slump, C. H. (2018). In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. In N. Duric, & B. C. Byram (Eds.), Medical Imaging 2018: Ultrasonic Imaging and Tomography (Vol. 10580, pp. 5). Article 105800A (Proceedings of SPIE; Vol. 10580). SPIE. https://doi.org/10.1117/12.2293669

@inproceedings{db3fd93cb51b4e3da1de7f5ad95ed30f,

title = "In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent",

abstract = "Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.",

keywords = "Carotid artery, Contrast-enhanced, High-frame-rate, Particle image velocimetry, Ultrasound",

author = "Hoving, {Astrid M.} and Jason Voorneveld and {De Vries}, {Evelien E.} and {Groot Jebbink}, Erik and Michel Versluis and Bosch, {Johan G.} and {de Jong}, Nico and Julia Mikhal and {De Borst}, {Gert J.} and Slump, {Cornelis H.}",

year = "2018",

month = mar,

day = "6",

doi = "10.1117/12.2293669",

language = "English",

isbn = "978-1-5106-1649-3",

volume = "10580",

series = "Proceedings of SPIE",

publisher = "SPIE",

pages = "5",

editor = "Neb Duric and Byram, {Brett C.}",

booktitle = "Medical Imaging 2018",

address = "United States",

note = "SPIE Medical Imaging 2018 : Ultrasonic Imaging and Tomography ; Conference date: 10-02-2018 Through 15-02-2018",

}

Hoving, AM, Voorneveld, J, De Vries, EE, Groot Jebbink, E , Versluis, M, Bosch, JG, de Jong, N, Mikhal, J, De Borst, GJ & Slump, CH 2018, In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. in N Duric & BC Byram (eds), Medical Imaging 2018: Ultrasonic Imaging and Tomography. vol. 10580, 105800A, Proceedings of SPIE, vol. 10580, SPIE, pp. 5, SPIE Medical Imaging 2018, Houston, Texas, United States, 10/02/18. https://doi.org/10.1117/12.2293669

In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent. / Hoving, Astrid M.; Voorneveld, Jason; De Vries, Evelien E. et al.
Medical Imaging 2018: Ultrasonic Imaging and Tomography. ed. / Neb Duric; Brett C. Byram. Vol. 10580 SPIE, 2018. p. 5 105800A (Proceedings of SPIE; Vol. 10580).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

AU - Hoving, Astrid M.

AU - Voorneveld, Jason

AU - De Vries, Evelien E.

AU - Groot Jebbink, Erik

AU - Versluis, Michel

AU - Bosch, Johan G.

AU - de Jong, Nico

AU - Mikhal, Julia

AU - De Borst, Gert J.

AU - Slump, Cornelis H.

PY - 2018/3/6

Y1 - 2018/3/6

N2 - Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.

AB - Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.

KW - Carotid artery

KW - Contrast-enhanced

KW - High-frame-rate

KW - Particle image velocimetry

KW - Ultrasound

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U2 - 10.1117/12.2293669

DO - 10.1117/12.2293669

M3 - Conference contribution

AN - SCOPUS:85049352930

SN - 978-1-5106-1649-3

VL - 10580

T3 - Proceedings of SPIE

SP - 5

BT - Medical Imaging 2018

A2 - Duric, Neb

A2 - Byram, Brett C.

PB - SPIE

T2 - SPIE Medical Imaging 2018

Y2 - 10 February 2018 through 15 February 2018

ER -

In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

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