In-vitro-testung eines oxygenators mit integrierter pulsatiler pumpe für pädiatrische anwendungen

Translated title of the contribution: In vitro testing of an oxygenator with integrated pulsatile pump for pediatric applications

Ralf Borchardt*, P. Schlanstein, I. Mager, J. Arens, T. Schmitz-Rode, U. Steinseifer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

For different lung and heart diseases (e. g., acute respiratory distress syndrome, congenital heart failure, and cardiomyopathy) extracorporeal membrane oxygenation is a well-established therapy, particularly in the field of neonatal and pediatric medicine. To reduce the priming volume of the extracorporeal circuit, different components can be combined. In this study, an oval-shaped oxygenator (called ExMeTrA) with integrated pulsatile pump was tested in vitro using porcine blood. A feasibility study regarding the performance of collapsing and expanding silicone tubes within an oxygenator fiber bundle as a pulsatile pump was previously completed with successful results. The findings of this study improve upon the previous feasibility results, particularly in terms of gas exchange and filling volume. Five modules were manufactured in sizes of 20 ± 2.2 ml (priming volume) with fiber surface areas of 0.24 ± 0.027 m2 and an analytically calculated volume pumping capacity of 692 ± 75 ml/min. The modules were made of polymethylpentene fibers with dense outer layer to permit long-term applications. The gas exchange rates at a gas/blood flow ratio of 2:1 were between 64 and 72.7 mloxygen/l blood and between 62.5 and 81.5 mlcarbon dioxide/l blood, depending on the blood flow. The individual module's pumping capacity ranged from 200 to 500 ml/min thus providing room for further improvements. In order to enhance the pumping capacity while maintaining sufficient gas exchange rates future optimization, adjustments will be made to the inlet and outlet geometries.

Translated title of the contributionIn vitro testing of an oxygenator with integrated pulsatile pump for pediatric applications
Original languageGerman
Pages (from-to)36-42
Number of pages7
JournalKardiotechnik
Volume22
Issue number2
Publication statusPublished - 1 May 2013
Externally publishedYes

Keywords

  • Artificial lung
  • ECMO
  • Hollow fiber
  • Lung assist
  • Miniaturization
  • Optimized flow pattern
  • Oxygenator
  • Pediatric
  • Pulsatile flow
  • Silicone tubes

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