In vivo and in vitro experience with the PUCA-II, a single-valved pulsatile catheter-pump

D. Mihaylov, G. Rakhorst*, A. van der Plaats, J.P. van Loon, M.M. Hummel, J. Elstrodt, G.J. Verkerke

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


The Pulsatile Catheter (PUCA) pump is a trans-arterial pulsatile ventricular assist device that can be used for short-term left ventricular support. The separate inflow and outflow valves in the first version of the device (PUCA-I) were replaced by a single inflow/outflow valve in the latest PUCA pump version (PUCA-II). The new combined valve was tested during in vitro (mock circulation) and in vivo experiments for valve leakage, flow resistance, and thrombus formation. During the in vitro experiments a maximum valve leakage of 6% during ejection and 21% during aspiration was found. The maximum flow resistance coefficient (K) was 4. The animal experiments demonstrated that the PUCA-II could be positioned within a few minutes into the left ventricle without X-ray guidance and without using a vascular graft. Thrombi were not found in the combined valve after total pump time of 3 hours, which proved the good washout of the valve. Initial experiments to position the pump in the right ventricle through the pulmonary artery were successful and contributed to the development of a new application for the device.

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalThe International journal of artificial organs
Issue number10
Publication statusPublished - 1 Jan 2000
Externally publishedYes


  • Catheter-pump
  • In vitro
  • In vivo
  • LVAD


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