In vivo fragmentation of microporous polyurethane- and copolyester elastomer-based vascular prostheses

W.L.J. Hinrichs, J. Kuit, H. Feil, Ch.R.H. Wildevuur, J. Feijen

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28 Citations (Scopus)
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Abstract

A previous study showed that microporous, compliant and (bio)degradable vascular prostheses prepared from a polyurethane/poly(-lactic acid) mixture can function as a temporary scaffold for the regeneration of small-calibre arteries. In this study the mechanism of fragmentation of vascular prostheses made of polyurethane, copolyesterether and blends of either polyurethane or copolyesterether with polymers differing in biodegradability, crystallinity and glass transition temperature is investigated. Animal studies revealed that after 6 wk of implantation only the prostheses made of blends containing a second polymer which was nonelastic at 37°C were fragmented extensively, whether the second polymer was (bio)degradable or not. It is concluded that fragmentation of the prostheses is mainly caused by alternating stresses induced by the arterial pulsations and that (bio)degradation plays a minor role.
Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalBiomaterials
Volume13
Issue number9
DOIs
Publication statusPublished - 1992

Keywords

  • METIS-105247
  • IR-9606

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