In vivo low-coherence spectroscopic measurements of local hemoglobin absorption spectra in human skin

Nienke Bosschaart, Dirk J. Faber, Ton G. van Leeuwen, Maurice C.G. Aalders

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Abstract

Localized spectroscopic measurements of optical properties are invaluable for diagnostic applications that involve layered tissue structures, but conventional spectroscopic techniques lack exact control over the size and depth of the probed tissue volume. We show that low-coherence spectroscopy (LCS) overcomes these limitations by measuring local attenuation and absorption coefficient spectra in layered phantoms. In addition, we demonstrate the first in vivo LCS measurements of the human epidermis and dermis only. From the measured absorption in two distinct regions of the dermal microcirculation, we determine total hemoglobin concentration (3.0±0.5 g/l and 7.8±1.2 g/l) and oxygen saturation.
Original languageEnglish
Article number100504
Number of pages4
JournalJournal of biomedical optics
Volume16
Issue number10
DOIs
Publication statusPublished - 2011
Externally publishedYes

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