In vivo low-coherence spectroscopic measurements of local hemoglobin absorption spectra in human skin

Nienke Bosschaart, Dirk Faber, Ton van Leeuwen, M.C. Aalders

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    19 Citations (Scopus)

    Abstract

    Localized spectroscopic measurements of optical properties are invaluable for diagnostic applications that involve layered tissue structures, but conventional spectroscopic techniques lack exact control over the size and depth of the probed tissue volume. We show that low-coherence spectroscopy (LCS) overcomes these limitations by measuring local attenuation and absorption coefficient spectra in layered phantoms. In addition, we demonstrate the first in vivo LCS measurements of the human epidermis and dermis only. From the measured absorption in two distinct regions of the dermal microcirculation, we determine total hemoglobin concentration (3.0±0.5 g/l and 7.8±1.2 g/l) and oxygen saturation.
    Original languageEnglish
    Article number100504
    Number of pages4
    JournalJournal of biomedical optics
    Volume16
    Issue number10
    DOIs
    Publication statusPublished - 2011

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