In vivo testing of crosslinked polyethers. II: Weight loss, IR analysis and swelling behavior after implantation

B.J.M. Pol, L. van der Does, A. Bantjes, P.B. van Wachem

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Abstract

As reported in Part I (In vivo testing of crosslinked polyethers. I. Tissue reactions and biodegradation, J. Biomed. Mater. Res., this issue, pp. 307-320), microscopical evaluation after implantation of crosslinked (co)polyethers in rats showed differences in the rate of biodegradation, depending on the presence of tertiary hydrogen atoms in the main chain and the hydrophilicity of the polyether system. In this article (Part II) the biostability will be discussed in terms of weight loss, the swelling behavior, and changes in the chemical structure of the crosslinked polyethers after implantation. The biostability increased in the order poly(POx) < poly(THF-co-OX) < poly(THF) for the relatively hydrophobic polyethers. This confirmed our hypothesis that the absence of tertiary hydrogen atoms would improve the biostability. On the other hand, signs of biodegradation were observed for all polyether system studied. Infrared surface analysis showed that biodegradation was triggered by oxidative attack on the polymeric chain, leading to the formation of carboxylic ester and acid groups. It also was found that in the THF-based (co)polyethers, α-methylene groups were more sensitive than β-methylene groups. For a hydrophilic poly(THF)/PEO blend, an increase in surface PEO content was found, which might be due to preferential degradation of the PEO domains.
Original languageEnglish
Pages (from-to)321-331
Number of pages11
JournalJournal of biomedical materials research
Volume32
Issue number32
DOIs
Publication statusPublished - 1996

Fingerprint

Polyethers
Swelling
Biodegradation
Testing
Polyethylene oxides
Hydrogen
Atoms
Surface analysis
Hydrophilicity
Rats
Esters
Tissue
Infrared radiation
Degradation
Acids

Keywords

  • METIS-105388
  • IR-71265

Cite this

Pol, B.J.M. ; van der Does, L. ; Bantjes, A. ; van Wachem, P.B. / In vivo testing of crosslinked polyethers. II : Weight loss, IR analysis and swelling behavior after implantation. In: Journal of biomedical materials research. 1996 ; Vol. 32, No. 32. pp. 321-331.
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In vivo testing of crosslinked polyethers. II : Weight loss, IR analysis and swelling behavior after implantation. / Pol, B.J.M.; van der Does, L.; Bantjes, A.; van Wachem, P.B.

In: Journal of biomedical materials research, Vol. 32, No. 32, 1996, p. 321-331.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - In vivo testing of crosslinked polyethers. II

T2 - Weight loss, IR analysis and swelling behavior after implantation

AU - Pol, B.J.M.

AU - van der Does, L.

AU - Bantjes, A.

AU - van Wachem, P.B.

PY - 1996

Y1 - 1996

N2 - As reported in Part I (In vivo testing of crosslinked polyethers. I. Tissue reactions and biodegradation, J. Biomed. Mater. Res., this issue, pp. 307-320), microscopical evaluation after implantation of crosslinked (co)polyethers in rats showed differences in the rate of biodegradation, depending on the presence of tertiary hydrogen atoms in the main chain and the hydrophilicity of the polyether system. In this article (Part II) the biostability will be discussed in terms of weight loss, the swelling behavior, and changes in the chemical structure of the crosslinked polyethers after implantation. The biostability increased in the order poly(POx) < poly(THF-co-OX) < poly(THF) for the relatively hydrophobic polyethers. This confirmed our hypothesis that the absence of tertiary hydrogen atoms would improve the biostability. On the other hand, signs of biodegradation were observed for all polyether system studied. Infrared surface analysis showed that biodegradation was triggered by oxidative attack on the polymeric chain, leading to the formation of carboxylic ester and acid groups. It also was found that in the THF-based (co)polyethers, α-methylene groups were more sensitive than β-methylene groups. For a hydrophilic poly(THF)/PEO blend, an increase in surface PEO content was found, which might be due to preferential degradation of the PEO domains.

AB - As reported in Part I (In vivo testing of crosslinked polyethers. I. Tissue reactions and biodegradation, J. Biomed. Mater. Res., this issue, pp. 307-320), microscopical evaluation after implantation of crosslinked (co)polyethers in rats showed differences in the rate of biodegradation, depending on the presence of tertiary hydrogen atoms in the main chain and the hydrophilicity of the polyether system. In this article (Part II) the biostability will be discussed in terms of weight loss, the swelling behavior, and changes in the chemical structure of the crosslinked polyethers after implantation. The biostability increased in the order poly(POx) < poly(THF-co-OX) < poly(THF) for the relatively hydrophobic polyethers. This confirmed our hypothesis that the absence of tertiary hydrogen atoms would improve the biostability. On the other hand, signs of biodegradation were observed for all polyether system studied. Infrared surface analysis showed that biodegradation was triggered by oxidative attack on the polymeric chain, leading to the formation of carboxylic ester and acid groups. It also was found that in the THF-based (co)polyethers, α-methylene groups were more sensitive than β-methylene groups. For a hydrophilic poly(THF)/PEO blend, an increase in surface PEO content was found, which might be due to preferential degradation of the PEO domains.

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