Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy

Holger Schönherr, J. Frommer (Editor), M.W.J. Beulen, R.M. Overney (Editor), H.J. Bugler, Jurriaan Huskens, F.C.J.M. van Veggel, David Reinhoudt, Gyula J. Vancso

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic


Until now single molecule force spectroscopy experiments have been performed almost exclusively on biologically relevant systems consisting of receptors with high molar masses and very slow unbinding kinetics. In this paper we report on force spectroscopy results of the complexation behavior of ferrocene moieties, self-assembled on an AFM tip, in β-cyclodextrin (β-CD) receptors, immobilized in highly ordered self-assembled monolayers on Au(111). For this system the unbinding kinetics are on a shorter time scale than the AFM time scale. Multiple pull-off events could be observed, while the addition of an external guest was shown to reversibly block the β-CD cavities. The adhesion between β-CD and ferrocene was found to be quantized. The force of 56 ± 10 pN could be identified as single host-guest complex rupture force. This rupture force was found to be independent of the (un-)loading rate which is indicative for a thermodynamically controlled experiment. Our report is the first example where single supramolecular host-guest interactions could be monitored for complexation reactions with fast unbinding kinetics.
Original languageEnglish
Title of host publicationInterfacial Properties on the Submicron Scale
PublisherAmerican Chemical Society
ISBN (Electronic)9780841218482
ISBN (Print)9780841236912
Publication statusPublished - 2001
Event218th ACS National Meeting 1999: Fall 1999 - New Orleans, United States
Duration: 22 Aug 199926 Aug 1999
Conference number: 218

Publication series

NameACS Symposium Series


Conference218th ACS National Meeting 1999
Country/TerritoryUnited States
CityNew Orleans


  • METIS-245351


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