Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy

Holger Schönherr; J. Frommer; M.W.J. Beulen; R.M. Overney; H.J. Bugler; Jurriaan Huskens; F.C.J.M. van Veggel; David Reinhoudt; Gyula J. Vancso

doi:10.1021/bk-2001-0781.ch007

Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy

Holger Schönherr, J. Frommer (Editor), M.W.J. Beulen, R.M. Overney (Editor), H.J. Bugler, Jurriaan Huskens, F.C.J.M. van Veggel, David Reinhoudt, Gyula J. Vancso

Materials Science and Technology of Polymers

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

Abstract

Until now single molecule force spectroscopy experiments have been performed almost exclusively on biologically relevant systems consisting of receptors with high molar masses and very slow unbinding kinetics. In this paper we report on force spectroscopy results of the complexation behavior of ferrocene moieties, self-assembled on an AFM tip, in β-cyclodextrin (β-CD) receptors, immobilized in highly ordered self-assembled monolayers on Au(111). For this system the unbinding kinetics are on a shorter time scale than the AFM time scale. Multiple pull-off events could be observed, while the addition of an external guest was shown to reversibly block the β-CD cavities. The adhesion between β-CD and ferrocene was found to be quantized. The force of 56 ± 10 pN could be identified as single host-guest complex rupture force. This rupture force was found to be independent of the (un-)loading rate which is indicative for a thermodynamically controlled experiment. Our report is the first example where single supramolecular host-guest interactions could be monitored for complexation reactions with fast unbinding kinetics.

Original language	English
Title of host publication	Interfacial Properties on the Submicron Scale
Publisher	American Chemical Society
Chapter	7
Pages	113-128
ISBN (Electronic)	9780841218482
ISBN (Print)	9780841236912
DOIs	https://doi.org/10.1021/bk-2001-0781.ch007
Publication status	Published - 2001
Event	218th ACS National Meeting 1999: Fall 1999 - New Orleans, United States Duration: 22 Aug 1999 → 26 Aug 1999 Conference number: 218

Publication series

Name	ACS Symposium Series
Publisher	ACS
Number	781

Conference

Conference	218th ACS National Meeting 1999
Country/Territory	United States
City	New Orleans
Period	22/08/99 → 26/08/99

Keywords

METIS-245351

Access to Document

10.1021/bk-2001-0781.ch007

Cite this

Schönherr, H., Frommer, J. (Ed.), Beulen, M. W. J., Overney, R. M. (Ed.), Bugler, H. J., Huskens, J., van Veggel, F. C. J. M., Reinhoudt, D., & Vancso, G. J. (2001). Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy. In Interfacial Properties on the Submicron Scale (pp. 113-128). (ACS Symposium Series; No. 781). American Chemical Society. https://doi.org/10.1021/bk-2001-0781.ch007

@inproceedings{9c6dbc5f0fb644eaba87288d851058da,

title = "Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy",

abstract = "Until now single molecule force spectroscopy experiments have been performed almost exclusively on biologically relevant systems consisting of receptors with high molar masses and very slow unbinding kinetics. In this paper we report on force spectroscopy results of the complexation behavior of ferrocene moieties, self-assembled on an AFM tip, in β-cyclodextrin (β-CD) receptors, immobilized in highly ordered self-assembled monolayers on Au(111). For this system the unbinding kinetics are on a shorter time scale than the AFM time scale. Multiple pull-off events could be observed, while the addition of an external guest was shown to reversibly block the β-CD cavities. The adhesion between β-CD and ferrocene was found to be quantized. The force of 56 ± 10 pN could be identified as single host-guest complex rupture force. This rupture force was found to be independent of the (un-)loading rate which is indicative for a thermodynamically controlled experiment. Our report is the first example where single supramolecular host-guest interactions could be monitored for complexation reactions with fast unbinding kinetics.",

keywords = "METIS-245351",

author = "Holger Sch{\"o}nherr and J. Frommer and M.W.J. Beulen and R.M. Overney and H.J. Bugler and Jurriaan Huskens and {van Veggel}, F.C.J.M. and David Reinhoudt and Vancso, {Gyula J.}",

year = "2001",

doi = "10.1021/bk-2001-0781.ch007",

language = "English",

isbn = "9780841236912",

series = "ACS Symposium Series",

publisher = "American Chemical Society",

number = "781",

pages = "113--128",

booktitle = "Interfacial Properties on the Submicron Scale",

address = "United States",

note = "218th ACS National Meeting 1999 : Fall 1999 ; Conference date: 22-08-1999 Through 26-08-1999",

}

Schönherr, H, Frommer, J (ed.), Beulen, MWJ, Overney, RM (ed.), Bugler, HJ, Huskens, J, van Veggel, FCJM, Reinhoudt, D & Vancso, GJ 2001, Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy. in Interfacial Properties on the Submicron Scale. ACS Symposium Series, no. 781, American Chemical Society, pp. 113-128, 218th ACS National Meeting 1999, New Orleans, Louisiana, United States, 22/08/99. https://doi.org/10.1021/bk-2001-0781.ch007

Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy. / Schönherr, Holger; Frommer, J. (Editor); Beulen, M.W.J. et al.
Interfacial Properties on the Submicron Scale. American Chemical Society, 2001. p. 113-128 (ACS Symposium Series; No. 781).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy

AU - Schönherr, Holger

AU - Beulen, M.W.J.

AU - Bugler, H.J.

AU - Huskens, Jurriaan

AU - van Veggel, F.C.J.M.

AU - Reinhoudt, David

AU - Vancso, Gyula J.

A2 - Frommer, J.

A2 - Overney, R.M.

N1 - Conference code: 218

PY - 2001

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N2 - Until now single molecule force spectroscopy experiments have been performed almost exclusively on biologically relevant systems consisting of receptors with high molar masses and very slow unbinding kinetics. In this paper we report on force spectroscopy results of the complexation behavior of ferrocene moieties, self-assembled on an AFM tip, in β-cyclodextrin (β-CD) receptors, immobilized in highly ordered self-assembled monolayers on Au(111). For this system the unbinding kinetics are on a shorter time scale than the AFM time scale. Multiple pull-off events could be observed, while the addition of an external guest was shown to reversibly block the β-CD cavities. The adhesion between β-CD and ferrocene was found to be quantized. The force of 56 ± 10 pN could be identified as single host-guest complex rupture force. This rupture force was found to be independent of the (un-)loading rate which is indicative for a thermodynamically controlled experiment. Our report is the first example where single supramolecular host-guest interactions could be monitored for complexation reactions with fast unbinding kinetics.

AB - Until now single molecule force spectroscopy experiments have been performed almost exclusively on biologically relevant systems consisting of receptors with high molar masses and very slow unbinding kinetics. In this paper we report on force spectroscopy results of the complexation behavior of ferrocene moieties, self-assembled on an AFM tip, in β-cyclodextrin (β-CD) receptors, immobilized in highly ordered self-assembled monolayers on Au(111). For this system the unbinding kinetics are on a shorter time scale than the AFM time scale. Multiple pull-off events could be observed, while the addition of an external guest was shown to reversibly block the β-CD cavities. The adhesion between β-CD and ferrocene was found to be quantized. The force of 56 ± 10 pN could be identified as single host-guest complex rupture force. This rupture force was found to be independent of the (un-)loading rate which is indicative for a thermodynamically controlled experiment. Our report is the first example where single supramolecular host-guest interactions could be monitored for complexation reactions with fast unbinding kinetics.

KW - METIS-245351

U2 - 10.1021/bk-2001-0781.ch007

DO - 10.1021/bk-2001-0781.ch007

M3 - Conference contribution

SN - 9780841236912

T3 - ACS Symposium Series

SP - 113

EP - 128

BT - Interfacial Properties on the Submicron Scale

PB - American Chemical Society

T2 - 218th ACS National Meeting 1999

Y2 - 22 August 1999 through 26 August 1999

ER -

Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy

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