Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy

Holger Schönherr, M.W.J. Beulen, H.J. Bugler, Jurriaan Huskens, F.C.J.M. van Veggel, David Reinhoudt, Gyula J. Vancso

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Supramolecular host-guest interactions in aqueous environment were studied by dynamic single molecule force spectroscopy. The unbinding between ferrocene moieties immobilized on atomic force microscopy tips and B-cyclodextrin receptors in highly ordered self-assembled monolayers on Au(111) was studied. The rupture force of individual ferrocene-B-cyclodextrin complexes was found to be 56 ± 10 pN. The value of this unbinding force was independent of the unloading rate. This was attributed to the fast (de)complexation kinetics of the host-guest complex.
Original languageUndefined
Pages (from-to)4963-4967
Number of pages5
JournalJournal of the American Chemical Society
Issue number20
Publication statusPublished - 2000


  • METIS-106410
  • IR-11933

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