Supramolecular host-guest interactions in aqueous environment were studied by dynamic single molecule force spectroscopy. The unbinding between ferrocene moieties immobilized on atomic force microscopy tips and B-cyclodextrin receptors in highly ordered self-assembled monolayers on Au(111) was studied. The rupture force of individual ferrocene-B-cyclodextrin complexes was found to be 56 ± 10 pN. The value of this unbinding force was independent of the unloading rate. This was attributed to the fast (de)complexation kinetics of the host-guest complex.
Schönherr, H., Beulen, M. W. J., Bugler, H. J., Huskens, J., van Veggel, F. C. J. M., Reinhoudt, D., & Vancso, G. J. (2000). Individual supramolecular host-guest interactions studied by dynamic single molecule force spectroscopy. Journal of the American Chemical Society, 122(20), 4963-4967. https://doi.org/10.1021/ja994040i