Inducing targeted failure in cadaveric testing of 3-segment spinal units with and without simulated metastases

Karlijn H.J. Groenen (Corresponding Author), Dennis Janssen, Yvette M. van der Linden, Jan G.M. Kooloos, Jasper Homminga, Nico Verdonschot, Esther Tanck

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
1 Downloads (Pure)

Abstract

We propose an experimental setup and protocol able to induce targeted failure of the middle vertebra in 3-segment spinal units and to capture the specimens’ deformation in their post-failure state. Sixteen 3-segment spinal units with and without artificial metastases were destructively tested in axial compression using one of two failure criteria; either: (A) A clear drop in force (>10–15% of peak force) (n = 4); or (B) A minimum displacement of 5 mm (n = 12). Subsequently, the specimens were fully fixated in polymethylmethacrylate (PMMA), thereby preserving their post-failure state. Pre- and post-experiment computed tomography (CT) scans were acquired to determine the occurrence of failure in one of the vertebral bodies. All specimens were successfully fixated in their post-failure state. When applying failure criterion A, two specimens showed signs of failure. When applying failure criterion B, all specimens showed signs of failure; in 9 out of 12 specimens this occurred in the middle vertebrae only. In conclusion, this research provides an experimental setup and protocol able to induce targeted failure of 3-segment spinal units and to capture the specimens’ deformation in their post-failure state. Furthermore, this study illustrates the importance of an adequate failure criterion for successful simulation of vertebral fractures in an experimental setup.

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalMedical engineering & physics
Volume51
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Deformation
  • Failure criterion
  • Fracture
  • Mechanical testing
  • Metastases
  • Spine
  • Vertebral strength

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