Abstract
Question: How does a single dose of fluoxetine influence the cortical activity during movement execution and imagination and how do these changes relate to changes in muscle activation patterns and motor function in chronic stroke patients?
Methods: The study was a double-blind, randomized, placebo-controlled, cross-over design. Ten chronic stroke patients were included and received a single dose of 20 mg fluoxetine or placebo on two different days. Identical measurements were done 4 times: before and after the administration of the placebo and of fluoxetine. To examine changes in cortical activity, 64-channel electroencephalography (EEG) was measured during movement execution and imagination, whereafter the event-related synchronization (ERS) was calculated of the theta, alpha and beta frequency bands. To
examine peripheral changes, EMG (electromyography) of the extensor carpi radialis and flexor carpi radialis was measured during maximum voluntary isometric wrist extension and flexion (maximum voluntary force (MVF)), and 20% of MVF. Functional motor outcomes were measured using the Fugl Meyer Motor Assessment.
Preliminary results (n=5): When using a MANOVA, no significant effects were found for fluoxetine on motor function (FM), on ERS, or on muscle activation patters. Significant differences were found between the affected and the healthy arm when the MVF and the root mean square (RMS) of the EMG of the extensor carpi radialis are considered.
Conclusions: In contrast to previous studies, no potential effect of a single dose of fluoxetine on the rehabilitation of motor function after stroke is found.
Methods: The study was a double-blind, randomized, placebo-controlled, cross-over design. Ten chronic stroke patients were included and received a single dose of 20 mg fluoxetine or placebo on two different days. Identical measurements were done 4 times: before and after the administration of the placebo and of fluoxetine. To examine changes in cortical activity, 64-channel electroencephalography (EEG) was measured during movement execution and imagination, whereafter the event-related synchronization (ERS) was calculated of the theta, alpha and beta frequency bands. To
examine peripheral changes, EMG (electromyography) of the extensor carpi radialis and flexor carpi radialis was measured during maximum voluntary isometric wrist extension and flexion (maximum voluntary force (MVF)), and 20% of MVF. Functional motor outcomes were measured using the Fugl Meyer Motor Assessment.
Preliminary results (n=5): When using a MANOVA, no significant effects were found for fluoxetine on motor function (FM), on ERS, or on muscle activation patters. Significant differences were found between the affected and the healthy arm when the MVF and the root mean square (RMS) of the EMG of the extensor carpi radialis are considered.
Conclusions: In contrast to previous studies, no potential effect of a single dose of fluoxetine on the rehabilitation of motor function after stroke is found.
| Original language | English |
|---|---|
| Pages (from-to) | S139-S139 |
| Number of pages | 1 |
| Journal | Clinical neurophysiology |
| Volume | 125 |
| Issue number | Suppl. 1 |
| DOIs | |
| Publication status | Published - 19 Mar 2014 |
| Event | 30th International Congress of Clinical Neurophysiology, ICCN 2014 - Berlin, Germany Duration: 19 Mar 2014 → 23 Mar 2014 Conference number: 30 |
