Initial results of finger imaging using photoacoustic computed tomography

Peter van Es, Samir Kumar Biswas, Hein J. Bernelot Moens, Wiendelt Steenbergen, Srirang Manohar

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Abstract

We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager specifically developed for this purpose. The images show rich detail of the digital blood vessels with diameters between 100 μm and 1.5 mm in various orientations and at various depths. Different vascular layers in the skin including the subpapillary plexus could also be visualized. Acoustic reflections on the finger bone of photoacoustic signals from skin were visible in sequential slice images along the finger except at the location of the joint gaps. Not unexpectedly, the healthy synovial membrane at the joint gaps was not detected due to its small size and normal vascularization. Future research will concentrate on studying digits afflicted with rheumatoid arthritis to detect the inflamed synovium with its heightened vascularization, whose characteristics are potential markers for disease activity.
Original languageUndefined
Article number060501
Pages (from-to)060501-1-060501-3
JournalJournal of biomedical optics
Volume19
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • METIS-303706
  • IR-91166

Cite this

van Es, Peter ; Biswas, Samir Kumar ; Bernelot Moens, Hein J. ; Steenbergen, Wiendelt ; Manohar, Srirang. / Initial results of finger imaging using photoacoustic computed tomography. In: Journal of biomedical optics. 2014 ; Vol. 19, No. 6. pp. 060501-1-060501-3.
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Initial results of finger imaging using photoacoustic computed tomography. / van Es, Peter; Biswas, Samir Kumar; Bernelot Moens, Hein J.; Steenbergen, Wiendelt; Manohar, Srirang.

In: Journal of biomedical optics, Vol. 19, No. 6, 060501, 2014, p. 060501-1-060501-3.

Research output: Contribution to journalArticleAcademicpeer-review

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AB - We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager specifically developed for this purpose. The images show rich detail of the digital blood vessels with diameters between 100 μm and 1.5 mm in various orientations and at various depths. Different vascular layers in the skin including the subpapillary plexus could also be visualized. Acoustic reflections on the finger bone of photoacoustic signals from skin were visible in sequential slice images along the finger except at the location of the joint gaps. Not unexpectedly, the healthy synovial membrane at the joint gaps was not detected due to its small size and normal vascularization. Future research will concentrate on studying digits afflicted with rheumatoid arthritis to detect the inflamed synovium with its heightened vascularization, whose characteristics are potential markers for disease activity.

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