Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model

Gert-Jan A. ter Boo, Daniel Arens, Willem-Jan Metsemakers, Stephan Zeiter, R. Geoff Richards, Dirk W. Grijpma, David Eglin, T. Fintan Moriarty

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Abstract

Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with osteosynthesis implants is associated with high infection rates. Antibiotic-loaded biomaterials (ALBs) are increasingly used in implant surgeries across medical specialties to deliver high concentrations of antibiotics to the surgical site and reduce the risk of implant-associated infection. ALBs which are either less or not restricted in terms of spatial distribution and which may be applied throughout complex wounds could offer improved protection against infection in open fracture care.
Original languageEnglish
Pages (from-to)185-194
JournalActa biomaterialia
Volume43
DOIs
Publication statusPublished - 2016

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