Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model

Gert-Jan A. ter Boo; Daniel Arens; Willem-Jan Metsemakers; Stephan Zeiter; R. Geoff Richards; Dirk W. Grijpma; David Eglin; T. Fintan Moriarty

doi:10.1016/j.actbio.2016.07.029

Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model

Gert-Jan A. ter Boo, Daniel Arens, Willem-Jan Metsemakers, Stephan Zeiter, R. Geoff Richards, Dirk W. Grijpma, David Eglin, T. Fintan Moriarty

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Abstract

Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with osteosynthesis implants is associated with high infection rates. Antibiotic-loaded biomaterials (ALBs) are increasingly used in implant surgeries across medical specialties to deliver high concentrations of antibiotics to the surgical site and reduce the risk of implant-associated infection. ALBs which are either less or not restricted in terms of spatial distribution and which may be applied throughout complex wounds could offer improved protection against infection in open fracture care.

Original language	English
Pages (from-to)	185-194
Journal	Acta biomaterialia
Volume	43
DOIs	https://doi.org/10.1016/j.actbio.2016.07.029
Publication status	Published - 2016

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title = "Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model",

abstract = "Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with osteosynthesis implants is associated with high infection rates. Antibiotic-loaded biomaterials (ALBs) are increasingly used in implant surgeries across medical specialties to deliver high concentrations of antibiotics to the surgical site and reduce the risk of implant-associated infection. ALBs which are either less or not restricted in terms of spatial distribution and which may be applied throughout complex wounds could offer improved protection against infection in open fracture care.",

author = "{ter Boo}, {Gert-Jan A.} and Daniel Arens and Willem-Jan Metsemakers and Stephan Zeiter and Richards, {R. Geoff} and Grijpma, {Dirk W.} and David Eglin and Moriarty, {T. Fintan}",

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doi = "10.1016/j.actbio.2016.07.029",

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T1 - Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model

AU - ter Boo, Gert-Jan A.

AU - Arens, Daniel

AU - Metsemakers, Willem-Jan

AU - Zeiter, Stephan

AU - Richards, R. Geoff

AU - Grijpma, Dirk W.

AU - Eglin, David

AU - Moriarty, T. Fintan

PY - 2016

Y1 - 2016

N2 - Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with osteosynthesis implants is associated with high infection rates. Antibiotic-loaded biomaterials (ALBs) are increasingly used in implant surgeries across medical specialties to deliver high concentrations of antibiotics to the surgical site and reduce the risk of implant-associated infection. ALBs which are either less or not restricted in terms of spatial distribution and which may be applied throughout complex wounds could offer improved protection against infection in open fracture care.

AB - Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with osteosynthesis implants is associated with high infection rates. Antibiotic-loaded biomaterials (ALBs) are increasingly used in implant surgeries across medical specialties to deliver high concentrations of antibiotics to the surgical site and reduce the risk of implant-associated infection. ALBs which are either less or not restricted in terms of spatial distribution and which may be applied throughout complex wounds could offer improved protection against infection in open fracture care.

U2 - 10.1016/j.actbio.2016.07.029

DO - 10.1016/j.actbio.2016.07.029

M3 - Article

VL - 43

SP - 185

EP - 194

JO - Acta biomaterialia

JF - Acta biomaterialia

SN - 1742-7061

ER -

Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model

Abstract

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