TY - JOUR
T1 - Injectable Self-Oxygenating Cardio-Protective and Tissue Adhesive Silk-Based Hydrogel for Alleviating Ischemia After Mi Injury
AU - Hassan, Shabir
AU - Rezaei, Zahra
AU - Luna, Eder
AU - Yilmaz-Aykut, Dilara
AU - Lee, Myung Chul
AU - Perea, Ana Marie
AU - Jamaiyar, Anurag
AU - Bassous, Nicole
AU - Hirano, Minoru
AU - Tourk, Fatima Mumtaza
AU - Choi, Cholong
AU - Becker, Malin
AU - Yazdi, Iman
AU - Fan, Kai
AU - Avila-Ramirez, Alan Eduardo
AU - Ge, David
AU - Abdi, Reza
AU - Fisch, Sudeshna
AU - Leijten, Jeroen
AU - Feinberg, Mark W.
AU - Mandal, Biman B.
AU - Liao, Ronglih
AU - Shin, Su Ryon
N1 - Publisher Copyright:
© 2024 Wiley-VCH GmbH.
PY - 2024/8/8
Y1 - 2024/8/8
N2 - Myocardial infarction (MI) is a significant cardiovascular disease that restricts blood flow, resulting in massive cell death and leading to stiff and noncontractile fibrotic scar tissue formation. Recently, sustained oxygen release in the MI area has shown regeneration ability; however, improving its therapeutic efficiency for regenerative medicine remains challenging. Here, a combinatorial strategy for cardiac repair by developing cardioprotective and oxygenating hybrid hydrogels that locally sustain the release of stromal cell-derived factor-1 alpha (SDF) and oxygen for simultaneous activation of neovascularization at the infarct area is presented. A sustained release of oxygen and SDF from injectable, mechanically robust, and tissue-adhesive silk-based hybrid hydrogels is achieved. Enhanced endothelialization under normoxia and anoxia is observed. Furthermore, there is a marked improvement in vascularization that leads to an increment in cardiomyocyte survival by ≈30% and a reduction of the fibrotic scar formation in an MI animal rodent model. Improved left ventricular systolic and diastolic functions by ≈10% and 20%, respectively, with a ≈25% higher ejection fraction on day 7 are also observed. Therefore, local delivery of therapeutic oxygenating and cardioprotective hydrogels demonstrates beneficial effects on cardiac functional recovery for reparative therapy.
AB - Myocardial infarction (MI) is a significant cardiovascular disease that restricts blood flow, resulting in massive cell death and leading to stiff and noncontractile fibrotic scar tissue formation. Recently, sustained oxygen release in the MI area has shown regeneration ability; however, improving its therapeutic efficiency for regenerative medicine remains challenging. Here, a combinatorial strategy for cardiac repair by developing cardioprotective and oxygenating hybrid hydrogels that locally sustain the release of stromal cell-derived factor-1 alpha (SDF) and oxygen for simultaneous activation of neovascularization at the infarct area is presented. A sustained release of oxygen and SDF from injectable, mechanically robust, and tissue-adhesive silk-based hybrid hydrogels is achieved. Enhanced endothelialization under normoxia and anoxia is observed. Furthermore, there is a marked improvement in vascularization that leads to an increment in cardiomyocyte survival by ≈30% and a reduction of the fibrotic scar formation in an MI animal rodent model. Improved left ventricular systolic and diastolic functions by ≈10% and 20%, respectively, with a ≈25% higher ejection fraction on day 7 are also observed. Therefore, local delivery of therapeutic oxygenating and cardioprotective hydrogels demonstrates beneficial effects on cardiac functional recovery for reparative therapy.
KW - 2024 OA procedure
KW - Oxygenating microparticles
KW - Silk hydrogel
KW - Stromal differentiation factor
KW - Vascularization
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=85192788816&partnerID=8YFLogxK
U2 - 10.1002/smll.202312261
DO - 10.1002/smll.202312261
M3 - Article
AN - SCOPUS:85192788816
SN - 1613-6810
VL - 20
JO - Small
JF - Small
IS - 32
M1 - 2312261
ER -