Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children

J.M. Driessen, Jacobus Adrianus Maria van der Palen, W.M. van Aalderen, Franciscus H.C. de Jongh, B.J. Thio

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Abstract

Methacholine and histamine can lead to inspiratory flow limitation in asthmatic children and adults. This has not been analyzed after indirect airway stimuli, such as exercise. The aim of the study was to analyze airflow limitation after exercise in cold, dry air. 72 asthmatic children with mild to moderate asthma (mean age 13.2 ± 2.2 yrs) performed a treadmill exercise challenge. A fall of >10% in FEV1 was the threshold for expiratory flow limitation and a fall of >25% of MIF50 was the threshold for inspiratory flow limitation. The occurrence of wheeze, stridor and cough were quantified before and after exercise. After exercise, the mean fall in FEV1 was 17.7 ± 14.6%, while the mean fall in MIF50 was 25.4 ± 15.8%; no correlation was found between fall in FEV1 and MIF50 (R2: 0.04; p = 0.717). 53 of the 72 children showed an inspiratory and/or expiratory airflow limitation. 38% (20/53) of these children showed an isolated expiratory flow limitation, 45% (24/53) showed both expiratory and inspiratory flow limitation and 17% (9/53) showed an isolated inspiratory flow limitation. The fall in FEV1 peaked 9 min after exercise and correlated to expiratory wheeze. The fall in MIF50 peaked 15 min after exercise and correlated to inspiratory stridor. The time difference in peak fall between FEV1 and MIF50 was statistically significant (5.9 min; p < 0.001, 99% CI: 2.3–9.5 min). In conclusion, this study shows that an exercise challenge in asthmatic children can give rise to inspiratory airflow limitation, which may give rise to asthma like symptoms
Original languageEnglish
Pages (from-to)1362-1368
JournalRespiratory medicine
Volume106
Issue number10
DOIs
Publication statusPublished - 2012

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Air
Exercise
Respiratory Sounds
Asthma
Pulmonary Ventilation
Methacholine Chloride
Cough
Histamine

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title = "Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children",
abstract = "Methacholine and histamine can lead to inspiratory flow limitation in asthmatic children and adults. This has not been analyzed after indirect airway stimuli, such as exercise. The aim of the study was to analyze airflow limitation after exercise in cold, dry air. 72 asthmatic children with mild to moderate asthma (mean age 13.2 ± 2.2 yrs) performed a treadmill exercise challenge. A fall of >10{\%} in FEV1 was the threshold for expiratory flow limitation and a fall of >25{\%} of MIF50 was the threshold for inspiratory flow limitation. The occurrence of wheeze, stridor and cough were quantified before and after exercise. After exercise, the mean fall in FEV1 was 17.7 ± 14.6{\%}, while the mean fall in MIF50 was 25.4 ± 15.8{\%}; no correlation was found between fall in FEV1 and MIF50 (R2: 0.04; p = 0.717). 53 of the 72 children showed an inspiratory and/or expiratory airflow limitation. 38{\%} (20/53) of these children showed an isolated expiratory flow limitation, 45{\%} (24/53) showed both expiratory and inspiratory flow limitation and 17{\%} (9/53) showed an isolated inspiratory flow limitation. The fall in FEV1 peaked 9 min after exercise and correlated to expiratory wheeze. The fall in MIF50 peaked 15 min after exercise and correlated to inspiratory stridor. The time difference in peak fall between FEV1 and MIF50 was statistically significant (5.9 min; p < 0.001, 99{\%} CI: 2.3–9.5 min). In conclusion, this study shows that an exercise challenge in asthmatic children can give rise to inspiratory airflow limitation, which may give rise to asthma like symptoms",
author = "J.M. Driessen and {van der Palen}, {Jacobus Adrianus Maria} and {van Aalderen}, W.M. and {de Jongh}, {Franciscus H.C.} and B.J. Thio",
year = "2012",
doi = "10.1016/j.rmed.2012.06.017",
language = "English",
volume = "106",
pages = "1362--1368",
journal = "Respiratory medicine",
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publisher = "W.B. Saunders Ltd",
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}

Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children. / Driessen, J.M.; van der Palen, Jacobus Adrianus Maria; van Aalderen, W.M.; de Jongh, Franciscus H.C.; Thio, B.J.

In: Respiratory medicine, Vol. 106, No. 10, 2012, p. 1362-1368.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children

AU - Driessen, J.M.

AU - van der Palen, Jacobus Adrianus Maria

AU - van Aalderen, W.M.

AU - de Jongh, Franciscus H.C.

AU - Thio, B.J.

PY - 2012

Y1 - 2012

N2 - Methacholine and histamine can lead to inspiratory flow limitation in asthmatic children and adults. This has not been analyzed after indirect airway stimuli, such as exercise. The aim of the study was to analyze airflow limitation after exercise in cold, dry air. 72 asthmatic children with mild to moderate asthma (mean age 13.2 ± 2.2 yrs) performed a treadmill exercise challenge. A fall of >10% in FEV1 was the threshold for expiratory flow limitation and a fall of >25% of MIF50 was the threshold for inspiratory flow limitation. The occurrence of wheeze, stridor and cough were quantified before and after exercise. After exercise, the mean fall in FEV1 was 17.7 ± 14.6%, while the mean fall in MIF50 was 25.4 ± 15.8%; no correlation was found between fall in FEV1 and MIF50 (R2: 0.04; p = 0.717). 53 of the 72 children showed an inspiratory and/or expiratory airflow limitation. 38% (20/53) of these children showed an isolated expiratory flow limitation, 45% (24/53) showed both expiratory and inspiratory flow limitation and 17% (9/53) showed an isolated inspiratory flow limitation. The fall in FEV1 peaked 9 min after exercise and correlated to expiratory wheeze. The fall in MIF50 peaked 15 min after exercise and correlated to inspiratory stridor. The time difference in peak fall between FEV1 and MIF50 was statistically significant (5.9 min; p < 0.001, 99% CI: 2.3–9.5 min). In conclusion, this study shows that an exercise challenge in asthmatic children can give rise to inspiratory airflow limitation, which may give rise to asthma like symptoms

AB - Methacholine and histamine can lead to inspiratory flow limitation in asthmatic children and adults. This has not been analyzed after indirect airway stimuli, such as exercise. The aim of the study was to analyze airflow limitation after exercise in cold, dry air. 72 asthmatic children with mild to moderate asthma (mean age 13.2 ± 2.2 yrs) performed a treadmill exercise challenge. A fall of >10% in FEV1 was the threshold for expiratory flow limitation and a fall of >25% of MIF50 was the threshold for inspiratory flow limitation. The occurrence of wheeze, stridor and cough were quantified before and after exercise. After exercise, the mean fall in FEV1 was 17.7 ± 14.6%, while the mean fall in MIF50 was 25.4 ± 15.8%; no correlation was found between fall in FEV1 and MIF50 (R2: 0.04; p = 0.717). 53 of the 72 children showed an inspiratory and/or expiratory airflow limitation. 38% (20/53) of these children showed an isolated expiratory flow limitation, 45% (24/53) showed both expiratory and inspiratory flow limitation and 17% (9/53) showed an isolated inspiratory flow limitation. The fall in FEV1 peaked 9 min after exercise and correlated to expiratory wheeze. The fall in MIF50 peaked 15 min after exercise and correlated to inspiratory stridor. The time difference in peak fall between FEV1 and MIF50 was statistically significant (5.9 min; p < 0.001, 99% CI: 2.3–9.5 min). In conclusion, this study shows that an exercise challenge in asthmatic children can give rise to inspiratory airflow limitation, which may give rise to asthma like symptoms

U2 - 10.1016/j.rmed.2012.06.017

DO - 10.1016/j.rmed.2012.06.017

M3 - Article

VL - 106

SP - 1362

EP - 1368

JO - Respiratory medicine

JF - Respiratory medicine

SN - 0954-6111

IS - 10

ER -