Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications

G. Krishnamoorthy, E.T. Carlen, R.B.M. Schasfoort, A. van den Berg

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.
Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010
EditorsSabeth Verpoorte, Helen Andersson-Svahn, Jenny Emnéus, Nicole Pamme
Place of PublicationSan Diego
PublisherChemical and Biological Micro Systems Society
Pages581-583
Number of pages3
ISBN (Electronic)978-0-9798064-3-8
ISBN (Print)978-1-6183906-2-2
Publication statusPublished - 3 Oct 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010
Conference number: 14

Publication series

NameInternational Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]
PublisherThe Chemical and Biological Microsystems Society
Volume2010
ISSN (Print)1556-5904

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010
Abbreviated titleMicroTAS
CountryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Lab-on-a-chip
  • Biosensor
  • Surface plasmon resonance imaging
  • Drug screening
  • Electrokinetics

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  • Cite this

    Krishnamoorthy, G., Carlen, E. T., Schasfoort, R. B. M., & van den Berg, A. (2010). Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. In S. Verpoorte, H. Andersson-Svahn, J. Emnéus, & N. Pamme (Eds.), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010 (pp. 581-583). (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). San Diego: Chemical and Biological Micro Systems Society.