Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications

G. Krishnamoorthy; E.T. Carlen; R.B.M. Schasfoort; A. van den Berg

Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications

G. Krishnamoorthy, E.T. Carlen, R.B.M. Schasfoort, A. van den Berg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

7 Downloads (Pure)

Abstract

We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.

Original language	English
Title of host publication	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010
Editors	Sabeth Verpoorte, Helen Andersson-Svahn, Jenny Emnéus, Nicole Pamme
Place of Publication	San Diego
Publisher	Chemical and Biological Micro Systems Society
Pages	581-583
Number of pages	3
ISBN (Electronic)	978-0-9798064-3-8
ISBN (Print)	978-1-6183906-2-2
Publication status	Published - 3 Oct 2010
Event	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010 - Groningen, Netherlands Duration: 3 Oct 2010 → 7 Oct 2010 Conference number: 14

Publication series

Name	International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]
Publisher	The Chemical and Biological Microsystems Society
Volume	2010
ISSN (Print)	1556-5904

Conference

Conference	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010
Abbreviated title	MicroTAS
Country	Netherlands
City	Groningen
Period	3/10/10 → 7/10/10

Keywords

Lab-on-a-chip
Biosensor
Surface plasmon resonance imaging
Drug screening
Electrokinetics

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Krishnamoorthy, G., Carlen, E. T., Schasfoort, R. B. M., & van den Berg, A. (2010). Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. In S. Verpoorte, H. Andersson-Svahn, J. Emnéus, & N. Pamme (Eds.), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010 (pp. 581-583). (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). San Diego: Chemical and Biological Micro Systems Society.

Krishnamoorthy, G. ; Carlen, E.T. ; Schasfoort, R.B.M. ; van den Berg, A. / Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. editor / Sabeth Verpoorte ; Helen Andersson-Svahn ; Jenny Emnéus ; Nicole Pamme. San Diego : Chemical and Biological Micro Systems Society, 2010. pp. 581-583 (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]).

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abstract = "We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.",

keywords = "Lab-on-a-chip, Biosensor, Surface plasmon resonance imaging, Drug screening, Electrokinetics",

author = "G. Krishnamoorthy and E.T. Carlen and R.B.M. Schasfoort and {van den Berg}, A.",

year = "2010",

month = "10",

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series = "International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]",

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Krishnamoorthy, G, Carlen, ET, Schasfoort, RBM & van den Berg, A 2010, Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. in S Verpoorte, H Andersson-Svahn, J Emnéus & N Pamme (eds), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings], vol. 2010, Chemical and Biological Micro Systems Society, San Diego, pp. 581-583, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010, Groningen, Netherlands, 3/10/10.

Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. / Krishnamoorthy, G.; Carlen, E.T.; Schasfoort, R.B.M.; van den Berg, A.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. ed. / Sabeth Verpoorte; Helen Andersson-Svahn; Jenny Emnéus; Nicole Pamme. San Diego : Chemical and Biological Micro Systems Society, 2010. p. 581-583 (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications

AU - Krishnamoorthy, G.

AU - Carlen, E.T.

AU - Schasfoort, R.B.M.

AU - van den Berg, A.

PY - 2010/10/3

Y1 - 2010/10/3

N2 - We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.

AB - We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.

KW - Lab-on-a-chip

KW - Biosensor

KW - Surface plasmon resonance imaging

KW - Drug screening

KW - Electrokinetics

M3 - Conference contribution

SN - 978-1-6183906-2-2

T3 - International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]

SP - 581

EP - 583

BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010

A2 - Verpoorte, Sabeth

A2 - Andersson-Svahn, Helen

A2 - Emnéus, Jenny

A2 - Pamme, Nicole

PB - Chemical and Biological Micro Systems Society

CY - San Diego

ER -

Krishnamoorthy G, Carlen ET, Schasfoort RBM , van den Berg A. Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. In Verpoorte S, Andersson-Svahn H, Emnéus J, Pamme N, editors, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. San Diego: Chemical and Biological Micro Systems Society. 2010. p. 581-583. (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]).