Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications

G. Krishnamoorthy, E.T. Carlen, R.B.M. Schasfoort, A. van den Berg

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)
3 Downloads (Pure)

Abstract

We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.
Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010
EditorsSabeth Verpoorte, Helen Andersson-Svahn, Jenny Emnéus, Nicole Pamme
Place of PublicationSan Diego
PublisherChemical and Biological Micro Systems Society
Pages581-583
Number of pages3
ISBN (Electronic)978-0-9798064-3-8
ISBN (Print)978-1-6183906-2-2
Publication statusPublished - 3 Oct 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010
Conference number: 14

Publication series

NameInternational Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]
PublisherThe Chemical and Biological Microsystems Society
Volume2010
ISSN (Print)1556-5904

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010
Abbreviated titleMicroTAS
CountryNetherlands
CityGroningen
Period3/10/107/10/10

Fingerprint

Lab-on-a-chip
Biosensors
Screening
Kinetics
Surface plasmon resonance
Microchannels
Pharmaceutical Preparations
Imaging systems
Throughput
Proteins

Keywords

  • Lab-on-a-chip
  • Biosensor
  • Surface plasmon resonance imaging
  • Drug screening
  • Electrokinetics

Cite this

Krishnamoorthy, G., Carlen, E. T., Schasfoort, R. B. M., & van den Berg, A. (2010). Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. In S. Verpoorte, H. Andersson-Svahn, J. Emnéus, & N. Pamme (Eds.), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010 (pp. 581-583). (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). San Diego: Chemical and Biological Micro Systems Society.
Krishnamoorthy, G. ; Carlen, E.T. ; Schasfoort, R.B.M. ; van den Berg, A. / Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. editor / Sabeth Verpoorte ; Helen Andersson-Svahn ; Jenny Emnéus ; Nicole Pamme. San Diego : Chemical and Biological Micro Systems Society, 2010. pp. 581-583 (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]).
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Krishnamoorthy, G, Carlen, ET, Schasfoort, RBM & van den Berg, A 2010, Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. in S Verpoorte, H Andersson-Svahn, J Emnéus & N Pamme (eds), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings], vol. 2010, Chemical and Biological Micro Systems Society, San Diego, pp. 581-583, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010, Groningen, Netherlands, 3/10/10.

Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. / Krishnamoorthy, G.; Carlen, E.T.; Schasfoort, R.B.M.; van den Berg, A.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. ed. / Sabeth Verpoorte; Helen Andersson-Svahn; Jenny Emnéus; Nicole Pamme. San Diego : Chemical and Biological Micro Systems Society, 2010. p. 581-583 (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications

AU - Krishnamoorthy, G.

AU - Carlen, E.T.

AU - Schasfoort, R.B.M.

AU - van den Berg, A.

PY - 2010/10/3

Y1 - 2010/10/3

N2 - We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.

AB - We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.

KW - Lab-on-a-chip

KW - Biosensor

KW - Surface plasmon resonance imaging

KW - Drug screening

KW - Electrokinetics

M3 - Conference contribution

SN - 978-1-6183906-2-2

T3 - International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]

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EP - 583

BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010

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A2 - Pamme, Nicole

PB - Chemical and Biological Micro Systems Society

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Krishnamoorthy G, Carlen ET, Schasfoort RBM, van den Berg A. Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. In Verpoorte S, Andersson-Svahn H, Emnéus J, Pamme N, editors, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010. San Diego: Chemical and Biological Micro Systems Society. 2010. p. 581-583. (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]).