Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform

Jia Jun Yeh; Pratik Tawade; Hande Aydogmus; Aniruddha Paul; Germaine Aalderink; Hans Bouwmeester; Mathieu Odijk; Jaap M.J. Den Toonder; Massimo Mastrangeli

doi:10.1109/Transducers61432.2025.11110020

Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform

Jia Jun Yeh
, Pratik Tawade
, Hande Aydogmus
, Aniruddha Paul
, Germaine Aalderink
, Hans Bouwmeester
, Mathieu Odijk
, Jaap M.J. Den Toonder
, Massimo Mastrangeli^*

^*Corresponding author for this work

Integrated Devices and Systems

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

We present the fluidic and electrical packaging of a novel silicon-based trans-epithelial electrical resistance (TEER) sensor chip designed for a modular and standardized organ-on-chip (OoC) platform. The package comprises three key components: the housing of the TEER chip, microfluidic routing for seamless integration with the platform, and electrical connections to a platform-integrated potentiostat. This modular solution enables continuous impedance measurements while maintaining unobstructed optical access to the tissue culture region. Experiments confirmed leak-free fluid flow across the stacked microfluidic channels and stable sensitivity of TiN electrodes to PBS. The TEER module retains optical transparency, bi-ocompatibility, and industrial scalability, supporting advanced in situ tissue barrier assessments in standardized OoC systems.

Original language	English
Title of host publication	2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)
Pages	1335-1338
Number of pages	4
Edition	2025
ISBN (Electronic)	979-8-3315-1381-8
DOIs	https://doi.org/10.1109/Transducers61432.2025.11110020
Publication status	Published - 19 Aug 2025
Event	23rd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2025 - Orlando, United States Duration: 29 Jun 2025 → 3 Jul 2025 Conference number: 23

Publication series

Name	International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers
Publisher	IEEE
ISSN (Print)	2167-0013

Conference

Conference	23rd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2025
Abbreviated title	Transducers 2025
Country/Territory	United States
City	Orlando
Period	29/06/25 → 3/07/25

Keywords

2026 OA procedure
microfluidic platform technologies
organ-on-chip
standardization
trans-epithelial electrical resistance
Barrier-on-chip

Access to Document

10.1109/Transducers61432.2025.11110020

Integrated_Microfluidic_Tissue_Barrier_Sensor_Module_for_a_Standardized_and_Modular_Organ-On-Chip_PlatformFinal published version, 1.07 MBLicence: Taverne

Cite this

Yeh, J. J., Tawade, P., Aydogmus, H., Paul, A., Aalderink, G., Bouwmeester, H., Odijk, M., Den Toonder, J. M. J., & Mastrangeli, M. (2025). Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform. In 2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) (2025 ed., pp. 1335-1338). (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers). https://doi.org/10.1109/Transducers61432.2025.11110020

Yeh, Jia Jun ; Tawade, Pratik ; Aydogmus, Hande et al. / Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform. 2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). 2025. ed. 2025. pp. 1335-1338 (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers).

@inproceedings{fee6712a97af4608b1b91f1bf1992f33,

title = "Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform",

abstract = "We present the fluidic and electrical packaging of a novel silicon-based trans-epithelial electrical resistance (TEER) sensor chip designed for a modular and standardized organ-on-chip (OoC) platform. The package comprises three key components: the housing of the TEER chip, microfluidic routing for seamless integration with the platform, and electrical connections to a platform-integrated potentiostat. This modular solution enables continuous impedance measurements while maintaining unobstructed optical access to the tissue culture region. Experiments confirmed leak-free fluid flow across the stacked microfluidic channels and stable sensitivity of TiN electrodes to PBS. The TEER module retains optical transparency, bi-ocompatibility, and industrial scalability, supporting advanced in situ tissue barrier assessments in standardized OoC systems.",

keywords = "2026 OA procedure, microfluidic platform technologies, organ-on-chip, standardization, trans-epithelial electrical resistance, Barrier-on-chip",

author = "Yeh, \{Jia Jun\} and Pratik Tawade and Hande Aydogmus and Aniruddha Paul and Germaine Aalderink and Hans Bouwmeester and Mathieu Odijk and \{Den Toonder\}, \{Jaap M.J.\} and Massimo Mastrangeli",

note = "Publisher Copyright: {\textcopyright} 2025 IEEE.; 23rd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2025, Transducers 2025 ; Conference date: 29-06-2025 Through 03-07-2025",

year = "2025",

month = aug,

day = "19",

doi = "10.1109/Transducers61432.2025.11110020",

language = "English",

series = "International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers",

publisher = "IEEE",

pages = "1335--1338",

booktitle = "2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)",

edition = "2025",

}

Yeh, JJ, Tawade, P, Aydogmus, H, Paul, A, Aalderink, G, Bouwmeester, H, Odijk, M, Den Toonder, JMJ & Mastrangeli, M 2025, Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform. in 2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). 2025 edn, International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers, pp. 1335-1338, 23rd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2025, Orlando, Florida, United States, 29/06/25. https://doi.org/10.1109/Transducers61432.2025.11110020

Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform. / Yeh, Jia Jun; Tawade, Pratik; Aydogmus, Hande et al.
2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). 2025. ed. 2025. p. 1335-1338 (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform

AU - Yeh, Jia Jun

AU - Tawade, Pratik

AU - Aydogmus, Hande

AU - Paul, Aniruddha

AU - Aalderink, Germaine

AU - Bouwmeester, Hans

AU - Odijk, Mathieu

AU - Den Toonder, Jaap M.J.

AU - Mastrangeli, Massimo

N1 - Conference code: 23

PY - 2025/8/19

Y1 - 2025/8/19

N2 - We present the fluidic and electrical packaging of a novel silicon-based trans-epithelial electrical resistance (TEER) sensor chip designed for a modular and standardized organ-on-chip (OoC) platform. The package comprises three key components: the housing of the TEER chip, microfluidic routing for seamless integration with the platform, and electrical connections to a platform-integrated potentiostat. This modular solution enables continuous impedance measurements while maintaining unobstructed optical access to the tissue culture region. Experiments confirmed leak-free fluid flow across the stacked microfluidic channels and stable sensitivity of TiN electrodes to PBS. The TEER module retains optical transparency, bi-ocompatibility, and industrial scalability, supporting advanced in situ tissue barrier assessments in standardized OoC systems.

AB - We present the fluidic and electrical packaging of a novel silicon-based trans-epithelial electrical resistance (TEER) sensor chip designed for a modular and standardized organ-on-chip (OoC) platform. The package comprises three key components: the housing of the TEER chip, microfluidic routing for seamless integration with the platform, and electrical connections to a platform-integrated potentiostat. This modular solution enables continuous impedance measurements while maintaining unobstructed optical access to the tissue culture region. Experiments confirmed leak-free fluid flow across the stacked microfluidic channels and stable sensitivity of TiN electrodes to PBS. The TEER module retains optical transparency, bi-ocompatibility, and industrial scalability, supporting advanced in situ tissue barrier assessments in standardized OoC systems.

KW - 2026 OA procedure

KW - microfluidic platform technologies

KW - organ-on-chip

KW - standardization

KW - trans-epithelial electrical resistance

KW - Barrier-on-chip

UR - https://www.scopus.com/pages/publications/105030282770

U2 - 10.1109/Transducers61432.2025.11110020

DO - 10.1109/Transducers61432.2025.11110020

M3 - Conference contribution

AN - SCOPUS:105030282770

T3 - International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers

SP - 1335

EP - 1338

BT - 2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)

T2 - 23rd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2025

Y2 - 29 June 2025 through 3 July 2025

ER -

Yeh JJ, Tawade P, Aydogmus H, Paul A, Aalderink G, Bouwmeester H et al. Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform. In 2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). 2025 ed. 2025. p. 1335-1338. (International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers). doi: 10.1109/Transducers61432.2025.11110020

Integrated Microfluidic Tissue Barrier Sensor Module for a Standardized and Modular Organ-On-Chip Platform

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