Integration of sensory force feedback is disturbed in CRPS-related dystonia

W. Mugge, F.C.T. van der Helm, A.C. Schouten

Research output: Contribution to conferencePosterOther research output

31 Downloads (Pure)

Abstract

Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia, a movement disorder of sustained muscle contraction and abnormal postures. The origin of fixed dystonia is poorly understood, yet recent insights involve disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiology of fixed dystonia. Sensory weighting is the process of integrating and weighting sensory feedback channels in the central nervous system. Position and force are physically related, allowing translation from one modality into the other. When stiffness is known, combining the sensory feedback of position and force (sensory integration) provides increased accuracy of the estimate of either modality. It was hypothesized that patients with CRPS-related dystonia bias sensory weighting of force and position toward position due to the unreliability of force feedback.

CRPS-patients with dystonia (n=10) and age and gender-matched healthy subjects blindly reproduced a trained force against a linear spring which on occasion was covertly replaced by a non-linear spring, revealing the sensory weighting between force and position feedback (Mugge et al. 2009). The current study provides experimental evidence for dysfunctional sensory integration in fixed dystonia, showing that CRPS-patients with fixed dystonia do not reweight force and position feedback as controls do. The study shows that patients always favor position feedback, making it the first to demonstrate disturbed integration of force feedback in fixed dystonia, an important step towards understanding the pathophysiology of fixed dystonia.

With a modeling study we investigated the effect of the sensorimotor interaction on the phase-frequency relationship of the CMC. The model includes two systems, representing the efferent and afferent pathways modeled as gains and realistic neural time delays. We found that the closed-loop formed by the sensorimotor interaction has a huge effect on the phase-frequency relationship, depending on the relative strength of the afferent pathways. Within the beta band the slope of the phase-frequency relation is reduced (i.e. is less negative than expected for a pure efferent pathway) and has a nonzero intersect. If the afferent pathways are stronger than the efferent pathways a phase advance will result, i.e. the slope can become positive. In conclusion, the phase-frequency relation emerges from the interaction in the sensorimotor loop and here we demonstrated how the relation depends on a complex interaction between the afferent and efferent pathways.
Original languageEnglish
Number of pages1
Publication statusPublished - 15 Oct 2012
EventSociety for Neuroscience Annual Meeting, Neuroscience 2012 - New Orleans, United States
Duration: 13 Oct 201217 Oct 2012

Conference

ConferenceSociety for Neuroscience Annual Meeting, Neuroscience 2012
Abbreviated titleNeuroscience 2012
CountryUnited States
CityNew Orleans
Period13/10/1217/10/12

Fingerprint

Complex Regional Pain Syndromes
Sensory Feedback
Dystonia
Afferent Pathways
Efferent Pathways
Movement Disorders
Muscle Contraction
Posture
Healthy Volunteers
Central Nervous System
Pain
Temperature

Keywords

  • Motor control
  • Sensorimotor
  • Dystonia

Cite this

Mugge, W., van der Helm, F. C. T., & Schouten, A. C. (2012). Integration of sensory force feedback is disturbed in CRPS-related dystonia. Poster session presented at Society for Neuroscience Annual Meeting, Neuroscience 2012, New Orleans, United States.
Mugge, W. ; van der Helm, F.C.T. ; Schouten, A.C. / Integration of sensory force feedback is disturbed in CRPS-related dystonia. Poster session presented at Society for Neuroscience Annual Meeting, Neuroscience 2012, New Orleans, United States.1 p.
@conference{6b617208fb23472ab21cff0c18a5fe16,
title = "Integration of sensory force feedback is disturbed in CRPS-related dystonia",
abstract = "Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25{\%} of cases develop fixed dystonia, a movement disorder of sustained muscle contraction and abnormal postures. The origin of fixed dystonia is poorly understood, yet recent insights involve disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiology of fixed dystonia. Sensory weighting is the process of integrating and weighting sensory feedback channels in the central nervous system. Position and force are physically related, allowing translation from one modality into the other. When stiffness is known, combining the sensory feedback of position and force (sensory integration) provides increased accuracy of the estimate of either modality. It was hypothesized that patients with CRPS-related dystonia bias sensory weighting of force and position toward position due to the unreliability of force feedback.CRPS-patients with dystonia (n=10) and age and gender-matched healthy subjects blindly reproduced a trained force against a linear spring which on occasion was covertly replaced by a non-linear spring, revealing the sensory weighting between force and position feedback (Mugge et al. 2009). The current study provides experimental evidence for dysfunctional sensory integration in fixed dystonia, showing that CRPS-patients with fixed dystonia do not reweight force and position feedback as controls do. The study shows that patients always favor position feedback, making it the first to demonstrate disturbed integration of force feedback in fixed dystonia, an important step towards understanding the pathophysiology of fixed dystonia.With a modeling study we investigated the effect of the sensorimotor interaction on the phase-frequency relationship of the CMC. The model includes two systems, representing the efferent and afferent pathways modeled as gains and realistic neural time delays. We found that the closed-loop formed by the sensorimotor interaction has a huge effect on the phase-frequency relationship, depending on the relative strength of the afferent pathways. Within the beta band the slope of the phase-frequency relation is reduced (i.e. is less negative than expected for a pure efferent pathway) and has a nonzero intersect. If the afferent pathways are stronger than the efferent pathways a phase advance will result, i.e. the slope can become positive. In conclusion, the phase-frequency relation emerges from the interaction in the sensorimotor loop and here we demonstrated how the relation depends on a complex interaction between the afferent and efferent pathways.",
keywords = "Motor control, Sensorimotor, Dystonia",
author = "W. Mugge and {van der Helm}, F.C.T. and A.C. Schouten",
year = "2012",
month = "10",
day = "15",
language = "English",
note = "Society for Neuroscience Annual Meeting, Neuroscience 2012, Neuroscience 2012 ; Conference date: 13-10-2012 Through 17-10-2012",

}

Mugge, W, van der Helm, FCT & Schouten, AC 2012, 'Integration of sensory force feedback is disturbed in CRPS-related dystonia' Society for Neuroscience Annual Meeting, Neuroscience 2012, New Orleans, United States, 13/10/12 - 17/10/12, .

Integration of sensory force feedback is disturbed in CRPS-related dystonia. / Mugge, W.; van der Helm, F.C.T.; Schouten, A.C.

2012. Poster session presented at Society for Neuroscience Annual Meeting, Neuroscience 2012, New Orleans, United States.

Research output: Contribution to conferencePosterOther research output

TY - CONF

T1 - Integration of sensory force feedback is disturbed in CRPS-related dystonia

AU - Mugge, W.

AU - van der Helm, F.C.T.

AU - Schouten, A.C.

PY - 2012/10/15

Y1 - 2012/10/15

N2 - Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia, a movement disorder of sustained muscle contraction and abnormal postures. The origin of fixed dystonia is poorly understood, yet recent insights involve disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiology of fixed dystonia. Sensory weighting is the process of integrating and weighting sensory feedback channels in the central nervous system. Position and force are physically related, allowing translation from one modality into the other. When stiffness is known, combining the sensory feedback of position and force (sensory integration) provides increased accuracy of the estimate of either modality. It was hypothesized that patients with CRPS-related dystonia bias sensory weighting of force and position toward position due to the unreliability of force feedback.CRPS-patients with dystonia (n=10) and age and gender-matched healthy subjects blindly reproduced a trained force against a linear spring which on occasion was covertly replaced by a non-linear spring, revealing the sensory weighting between force and position feedback (Mugge et al. 2009). The current study provides experimental evidence for dysfunctional sensory integration in fixed dystonia, showing that CRPS-patients with fixed dystonia do not reweight force and position feedback as controls do. The study shows that patients always favor position feedback, making it the first to demonstrate disturbed integration of force feedback in fixed dystonia, an important step towards understanding the pathophysiology of fixed dystonia.With a modeling study we investigated the effect of the sensorimotor interaction on the phase-frequency relationship of the CMC. The model includes two systems, representing the efferent and afferent pathways modeled as gains and realistic neural time delays. We found that the closed-loop formed by the sensorimotor interaction has a huge effect on the phase-frequency relationship, depending on the relative strength of the afferent pathways. Within the beta band the slope of the phase-frequency relation is reduced (i.e. is less negative than expected for a pure efferent pathway) and has a nonzero intersect. If the afferent pathways are stronger than the efferent pathways a phase advance will result, i.e. the slope can become positive. In conclusion, the phase-frequency relation emerges from the interaction in the sensorimotor loop and here we demonstrated how the relation depends on a complex interaction between the afferent and efferent pathways.

AB - Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia, a movement disorder of sustained muscle contraction and abnormal postures. The origin of fixed dystonia is poorly understood, yet recent insights involve disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiology of fixed dystonia. Sensory weighting is the process of integrating and weighting sensory feedback channels in the central nervous system. Position and force are physically related, allowing translation from one modality into the other. When stiffness is known, combining the sensory feedback of position and force (sensory integration) provides increased accuracy of the estimate of either modality. It was hypothesized that patients with CRPS-related dystonia bias sensory weighting of force and position toward position due to the unreliability of force feedback.CRPS-patients with dystonia (n=10) and age and gender-matched healthy subjects blindly reproduced a trained force against a linear spring which on occasion was covertly replaced by a non-linear spring, revealing the sensory weighting between force and position feedback (Mugge et al. 2009). The current study provides experimental evidence for dysfunctional sensory integration in fixed dystonia, showing that CRPS-patients with fixed dystonia do not reweight force and position feedback as controls do. The study shows that patients always favor position feedback, making it the first to demonstrate disturbed integration of force feedback in fixed dystonia, an important step towards understanding the pathophysiology of fixed dystonia.With a modeling study we investigated the effect of the sensorimotor interaction on the phase-frequency relationship of the CMC. The model includes two systems, representing the efferent and afferent pathways modeled as gains and realistic neural time delays. We found that the closed-loop formed by the sensorimotor interaction has a huge effect on the phase-frequency relationship, depending on the relative strength of the afferent pathways. Within the beta band the slope of the phase-frequency relation is reduced (i.e. is less negative than expected for a pure efferent pathway) and has a nonzero intersect. If the afferent pathways are stronger than the efferent pathways a phase advance will result, i.e. the slope can become positive. In conclusion, the phase-frequency relation emerges from the interaction in the sensorimotor loop and here we demonstrated how the relation depends on a complex interaction between the afferent and efferent pathways.

KW - Motor control

KW - Sensorimotor

KW - Dystonia

M3 - Poster

ER -

Mugge W, van der Helm FCT, Schouten AC. Integration of sensory force feedback is disturbed in CRPS-related dystonia. 2012. Poster session presented at Society for Neuroscience Annual Meeting, Neuroscience 2012, New Orleans, United States.