Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

Jonas Schnittert, Ruchi Bansal, Gert Storm, Jai Prakash* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

37 Citations (Scopus)
429 Downloads (Pure)

Abstract

Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.

Original languageEnglish
Pages (from-to)37-53
Number of pages17
JournalAdvanced drug delivery reviews
Volume129
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • UT-Hybrid-D

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