Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

Jonas Schnittert, Ruchi Bansal, Gert Storm, Jai Prakash (Corresponding Author)

Research output: Contribution to journalReview articleAcademicpeer-review

9 Citations (Scopus)
175 Downloads (Pure)

Abstract

Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.

Original languageEnglish
Pages (from-to)37-53
Number of pages17
JournalAdvanced drug delivery reviews
Volume129
DOIs
Publication statusPublished - 1 Apr 2018

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Integrins
Wound Healing
Fibrosis
Pharmaceutical Preparations
Neoplasms
Therapeutics
Ligands
Growth Factor Receptors
Wounds and Injuries

Keywords

  • UT-Hybrid-D

Cite this

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title = "Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery",
abstract = "Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.",
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Integrins in wound healing, fibrosis and tumor stroma : High potential targets for therapeutics and drug delivery. / Schnittert, Jonas; Bansal, Ruchi; Storm, Gert; Prakash, Jai (Corresponding Author).

In: Advanced drug delivery reviews, Vol. 129, 01.04.2018, p. 37-53.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Integrins in wound healing, fibrosis and tumor stroma

T2 - High potential targets for therapeutics and drug delivery

AU - Schnittert, Jonas

AU - Bansal, Ruchi

AU - Storm, Gert

AU - Prakash, Jai

N1 - Elsevier deal

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Y1 - 2018/4/1

N2 - Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.

AB - Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.

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