Intensification of enzymatic conversion of glucose to lactic acid by reactive extraction

Kailas L. Wasewar, Vishwas G. Pangarkar, Albertus B.M. Heesink, Geert Versteeg

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101 Citations (Scopus)


Lactic acid is an important commercial product and extracting this out of aqueous solution is a growing requirement in fermentation-based industries and recovery from waste streams. The design of an amine extraction process requires (i) equilibrium and (ii) kinetic data for the acid–amine (solvent) system used. Equilibria and kinetics for lactic acid extraction by Alamine 336 in octanol as a diluent have been determined and compared with other diluents studied earlier. An approach for extracting the lactic acid by a long-chain tertiary amine, which is in the dispersed phase as a liquid ion exchanger (LIX), is presented. A mathematical model for slurry phase reactor with glucose in the continuous aqueous phase, the amine with a diluent in the dispersed phase and the immobilized enzyme as the solid catalyst, has been developed using equilibrium and kinetic data for reactive extraction. Effects of various parameters affecting the conversion of glucose have been discussed. The model has been solved for batch and semi-batch modes. It has been shown that the semi-batch mode yields approximately five times higher productivity than batch mode.
Original languageUndefined
Pages (from-to)3385-3393
JournalChemical engineering science
Issue number15
Publication statusPublished - 2003


  • METIS-217437
  • Lactic acid
  • IR-75495
  • Octanol
  • Alamine 336
  • Reactive extraction
  • Equilibria
  • Fermentation

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