Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities

P.B. van Wachem; T. Beugeling; Jan Feijen; A. Bantjes; J.P. Detmers; W.G. van Aken

doi:10.1016/0142-9612(85)90101-2

Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities

P.B. van Wachem, T. Beugeling, Jan Feijen, A. Bantjes, J.P. Detmers, W.G. van Aken

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Abstract

The in vitro interaction of human endothelial cells (HEC) and polymers with different wettabilities in culture medium containing serum was investigated. Optimal adhesion of HEC generally occurred onto moderately wettable polymers. Within a series of cellulose type of polymers the cell adhesion increased with increasing contact angle of the polymer surfaces. Proliferation of HEC occurred when adhesion was followed by progressive flattening of the cells. Our results suggest that moderately wettable polymers exhibit a serum and/or cellular protein adsorption pattern that is favourable for growth of HEC.

Original language	English
Pages (from-to)	403-408
Journal	Biomaterials
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0142-9612(85)90101-2
Publication status	Published - 1985

Keywords

Adhesion
Wettability
cells (human endothelial)
Proliferation
IR-69420
Polymer surface

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10.1016/0142-9612(85)90101-2

Wachem85interactionFinal published version, 652 KB

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title = "Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities",

abstract = "The in vitro interaction of human endothelial cells (HEC) and polymers with different wettabilities in culture medium containing serum was investigated. Optimal adhesion of HEC generally occurred onto moderately wettable polymers. Within a series of cellulose type of polymers the cell adhesion increased with increasing contact angle of the polymer surfaces. Proliferation of HEC occurred when adhesion was followed by progressive flattening of the cells. Our results suggest that moderately wettable polymers exhibit a serum and/or cellular protein adsorption pattern that is favourable for growth of HEC.",

keywords = "Adhesion, Wettability, cells (human endothelial), Proliferation, IR-69420, Polymer surface",

author = "{van Wachem}, P.B. and T. Beugeling and Jan Feijen and A. Bantjes and J.P. Detmers and {van Aken}, W.G.",

year = "1985",

doi = "10.1016/0142-9612(85)90101-2",

language = "English",

volume = "6",

pages = "403--408",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier",

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TY - JOUR

T1 - Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities

AU - van Wachem, P.B.

AU - Beugeling, T.

AU - Feijen, Jan

AU - Bantjes, A.

AU - Detmers, J.P.

AU - van Aken, W.G.

PY - 1985

Y1 - 1985

N2 - The in vitro interaction of human endothelial cells (HEC) and polymers with different wettabilities in culture medium containing serum was investigated. Optimal adhesion of HEC generally occurred onto moderately wettable polymers. Within a series of cellulose type of polymers the cell adhesion increased with increasing contact angle of the polymer surfaces. Proliferation of HEC occurred when adhesion was followed by progressive flattening of the cells. Our results suggest that moderately wettable polymers exhibit a serum and/or cellular protein adsorption pattern that is favourable for growth of HEC.

AB - The in vitro interaction of human endothelial cells (HEC) and polymers with different wettabilities in culture medium containing serum was investigated. Optimal adhesion of HEC generally occurred onto moderately wettable polymers. Within a series of cellulose type of polymers the cell adhesion increased with increasing contact angle of the polymer surfaces. Proliferation of HEC occurred when adhesion was followed by progressive flattening of the cells. Our results suggest that moderately wettable polymers exhibit a serum and/or cellular protein adsorption pattern that is favourable for growth of HEC.

KW - Adhesion

KW - Wettability

KW - cells (human endothelial)

KW - Proliferation

KW - IR-69420

KW - Polymer surface

U2 - 10.1016/0142-9612(85)90101-2

DO - 10.1016/0142-9612(85)90101-2

M3 - Article

VL - 6

SP - 403

EP - 408

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 6

ER -

Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities

Abstract

Keywords

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