Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities

P.B. van Wachem, T. Beugeling, Jan Feijen, A. Bantjes, J.P. Detmers, W.G. van Aken

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Abstract

The in vitro interaction of human endothelial cells (HEC) and polymers with different wettabilities in culture medium containing serum was investigated. Optimal adhesion of HEC generally occurred onto moderately wettable polymers. Within a series of cellulose type of polymers the cell adhesion increased with increasing contact angle of the polymer surfaces. Proliferation of HEC occurred when adhesion was followed by progressive flattening of the cells. Our results suggest that moderately wettable polymers exhibit a serum and/or cellular protein adsorption pattern that is favourable for growth of HEC.
Original languageEnglish
Pages (from-to)403-408
JournalBiomaterials
Volume6
Issue number6
DOIs
Publication statusPublished - 1985

Keywords

  • Adhesion
  • Wettability
  • cells (human endothelial)
  • Proliferation
  • IR-69420
  • Polymer surface

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