Two complementary theoretical approaches are used to study the effect of polydispersity on (anti)fouling properties of a neutral polymer brush. Polydispersity is described using the Schulz-Zimm distribution. The Scheutjens-Fleer self-consistent-field (SF-SCF) formalism is used to consider the interaction between a single particle and a polydisperse brush with grafting density a, focusing on the influence of the polydispersity index. The larger the polydispersity, the easier it is for a small particle (with radius R ∼ 1/ (2√σ)) to penetrate the brush. Hence, the monodisperse brush is better suited to protect a surface against the adsorption of small particles compared to a corresponding polydisperse brush. The brush grafting density, however, remains the most important parameter for tuning the brush antifouling properties against small particles. For large particles (modeled as a flat wall) an opposite effect of polydispersity is found: it is harder to compress a polydisperse brush than a corresponding monodisperse brush, and thus a polydisperse brush is better suited to protect the surface against adsorption of large particles. A less-detailed approach, based on the stacking of Alexander-de Gennes boxes, is used to study the adsorption of many particles into a polydisperse brush. Consistent with the single-particle data generated by the SF-SCF theory, for weak attraction between the particles and the brush the absolute adsorbed amount remains low but increases strongly as a function of polydispersity (from Mw/Mn = 1-2 by a factor of 2-4). Obviously, at higher attraction between the particles and the brush the adsorption increases, but a less strong dependence on the polydispersity index is observed.