Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices

Gonzalo E. Fenoy*, Roger Hasler, Christoph Lorenz, Jacopo Movilli, Waldemar A. Marmisollé, Omar Azzaroni*, Jurriaan Huskens, Peter Bäuerle, Wolfgang Knoll*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
8 Downloads (Pure)

Abstract

“Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition.

Original languageEnglish
Pages (from-to)10885-10896
Number of pages12
JournalACS Applied Materials and Interfaces
Volume15
Issue number8
Early online date15 Feb 2023
DOIs
Publication statusPublished - 1 Mar 2023

Keywords

  • biosensors
  • click chemistry
  • organic electrochemical transistors
  • poly-
  • thrombin

Fingerprint

Dive into the research topics of 'Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices'. Together they form a unique fingerprint.

Cite this