Interferon Analogs

Klaas Poelstra (Inventor), Jai Prakash (Inventor), Eleonora Beljaars (Inventor), Ruchi Bansal (Inventor)

    Research output: PatentProfessional

    Abstract

    The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

    Original languageEnglish
    Patent numberUS2013064791
    IPCC12N 15/ 63 A I
    Priority date30/12/10
    Publication statusPublished - 14 Mar 2013

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    Interferons
    Interferon Receptors
    Cell Surface Receptors
    Therapeutic Uses
    Medicine

    Cite this

    Poelstra, K., Prakash, J., Beljaars, E., & Bansal, R. (2013). IPC No. C12N 15/ 63 A I. Interferon Analogs. (Patent No. US2013064791).
    Poelstra, Klaas (Inventor) ; Prakash, Jai (Inventor) ; Beljaars, Eleonora (Inventor) ; Bansal, Ruchi (Inventor). / Interferon Analogs. IPC No.: C12N 15/ 63 A I. Patent No.: US2013064791.
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    abstract = "The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.",
    author = "Klaas Poelstra and Jai Prakash and Eleonora Beljaars and Ruchi Bansal",
    year = "2013",
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    Poelstra, K, Prakash, J, Beljaars, E & Bansal, R 2013, Interferon Analogs, Patent No. US2013064791, IPC No. C12N 15/ 63 A I.

    Interferon Analogs. / Poelstra, Klaas (Inventor); Prakash, Jai (Inventor); Beljaars, Eleonora (Inventor); Bansal, Ruchi (Inventor).

    IPC No.: C12N 15/ 63 A I. Patent No.: US2013064791.

    Research output: PatentProfessional

    TY - PAT

    T1 - Interferon Analogs

    AU - Poelstra, Klaas

    AU - Prakash, Jai

    AU - Beljaars, Eleonora

    AU - Bansal, Ruchi

    PY - 2013/3/14

    Y1 - 2013/3/14

    N2 - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

    AB - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

    M3 - Patent

    M1 - US2013064791

    ER -

    Poelstra K, Prakash J, Beljaars E, Bansal R, inventors. Interferon Analogs. C12N 15/ 63 A I. 2013 Mar 14.