Interferon Analogs

Klaas Poelstra; Jai Prakash; Eleonora Beljaars; Ruchi Bansal

Interferon Analogs

Klaas Poelstra (Inventor), Jai Prakash (Inventor), Eleonora Beljaars (Inventor), Ruchi Bansal (Inventor)

Research output: Patent

Abstract

The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

Original language	English
Patent number	US2013064791
IPC	C12N 15/ 63 A I
Priority date	30/12/10
Publication status	Published - 14 Mar 2013

Cite this

@misc{051dbb58b3e54a249bc3b7873bf9b329,

title = "Interferon Analogs",

abstract = "The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.",

author = "Klaas Poelstra and Jai Prakash and Eleonora Beljaars and Ruchi Bansal",

year = "2013",

month = mar,

day = "14",

language = "English",

type = "Patent",

note = "US2013064791; C12N 15/ 63 A I",

}

TY - PAT

T1 - Interferon Analogs

AU - Poelstra, Klaas

AU - Prakash, Jai

AU - Beljaars, Eleonora

AU - Bansal, Ruchi

PY - 2013/3/14

Y1 - 2013/3/14

N2 - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

AB - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

M3 - Patent

M1 - US2013064791

ER -

Interferon Analogs

Abstract

Fingerprint

Cite this