INTERFERON ANALOGS

Klaas Poelstra; Jai Prakash,; Eleonora Beljaars; Ruchi Bansal,

INTERFERON ANALOGS

Klaas Poelstra (Inventor), Jai Prakash, (Inventor), Eleonora Beljaars (Inventor), Ruchi Bansal, (Inventor)

Biomaterials Science and Technology

Research output: Patent

Abstract

The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

Original language	English
Patent number	WO2011081523
IPC	C07K 14/ 57 A I
Priority date	10/02/10
Publication status	Published - 7 Jul 2011

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title = "INTERFERON ANALOGS",

abstract = "The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.",

author = "Klaas Poelstra and Jai Prakash, and Eleonora Beljaars and Ruchi Bansal,",

year = "2011",

month = jul,

day = "7",

language = "English",

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note = "WO2011081523; C07K 14/ 57 A I",

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T1 - INTERFERON ANALOGS

AU - Poelstra, Klaas

AU - Prakash,, Jai

AU - Beljaars, Eleonora

AU - Bansal,, Ruchi

PY - 2011/7/7

Y1 - 2011/7/7

N2 - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

AB - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

M3 - Patent

M1 - WO2011081523

ER -

INTERFERON ANALOGS

Abstract

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