INTERFERON ANALOGS

Klaas Poelstra (Inventor), Jai Prakash, (Inventor), Eleonora Beljaars (Inventor), Ruchi Bansal, (Inventor)

Research output: Patent

Abstract

The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

Original languageEnglish
Patent numberWO2011081523
IPCC07K 14/ 57 A I
Priority date10/02/10
Publication statusPublished - 7 Jul 2011

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