INTERFERON ANALOGS

Klaas Poelstra (Inventor), Jai Prakash, (Inventor), Eleonora Beljaars (Inventor), Ruchi Bansal, (Inventor)

Research output: PatentProfessional

Abstract

The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

Original languageEnglish
Patent numberWO2011081523
IPCC07K 14/ 57 A I
Priority date10/02/10
Publication statusPublished - 7 Jul 2011

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Interferons
Interferon Receptors
Cell Surface Receptors
Therapeutic Uses
Medicine

Cite this

Poelstra, K., Prakash, J., Beljaars, E., & Bansal, R. (2011). IPC No. C07K 14/ 57 A I. INTERFERON ANALOGS. (Patent No. WO2011081523).
Poelstra, Klaas (Inventor) ; Prakash, Jai (Inventor) ; Beljaars, Eleonora (Inventor) ; Bansal, Ruchi (Inventor). / INTERFERON ANALOGS. IPC No.: C07K 14/ 57 A I. Patent No.: WO2011081523.
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Poelstra, K, Prakash, J, Beljaars, E & Bansal, R 2011, INTERFERON ANALOGS, Patent No. WO2011081523, IPC No. C07K 14/ 57 A I.

INTERFERON ANALOGS. / Poelstra, Klaas (Inventor); Prakash, Jai (Inventor); Beljaars, Eleonora (Inventor); Bansal, Ruchi (Inventor).

IPC No.: C07K 14/ 57 A I. Patent No.: WO2011081523.

Research output: PatentProfessional

TY - PAT

T1 - INTERFERON ANALOGS

AU - Poelstra, Klaas

AU - Prakash,, Jai

AU - Beljaars, Eleonora

AU - Bansal,, Ruchi

PY - 2011/7/7

Y1 - 2011/7/7

N2 - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

AB - The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.

M3 - Patent

M1 - WO2011081523

ER -

Poelstra K, Prakash, J, Beljaars E, Bansal, R, inventors. INTERFERON ANALOGS. C07K 14/ 57 A I. 2011 Jul 7.