TY - JOUR
T1 - Intraannular functionalization of macrocyclic polyethers via organolithium chemistry; x-ray structure of 2-sulfinyl-1,3-xylyl-15-crown-4
AU - Skowronska-Ptasinska, Maria
AU - Telleman, Pieter
AU - Aarts, Veronika M.L.J.
AU - Grootenhuis, Peter D.J.
AU - van Eerden, Johan
AU - Harkema, Sybolt
AU - Reinhoudt, David N.
PY - 1987
Y1 - 1987
N2 - The conversion of 2-lithio-1,3-xylyl crown ethers (2), obtained by reaction of the 2-bromo-1,3-xylyl crown ethers (1) with n_-butyllithium at −70 °C, with an electrophile is a generally applicable method for the synthesis of 1,3-xylyl crown ethers with intraannular acidic groups.
AB - The conversion of 2-lithio-1,3-xylyl crown ethers (2), obtained by reaction of the 2-bromo-1,3-xylyl crown ethers (1) with n_-butyllithium at −70 °C, with an electrophile is a generally applicable method for the synthesis of 1,3-xylyl crown ethers with intraannular acidic groups.
U2 - 10.1016/S0040-4039(00)96014-3
DO - 10.1016/S0040-4039(00)96014-3
M3 - Article
VL - 28
SP - 1937
EP - 1939
JO - Tetrahedron letters
JF - Tetrahedron letters
SN - 0040-4039
IS - 17
ER -