Intraannular functionalization of macrocyclic polyethers via organolithium chemistry; x-ray structure of 2-sulfinyl-1,3-xylyl-15-crown-4

Maria Skowronska-Ptasinska, Pieter Telleman, Veronika M.L.J. Aarts, Peter D.J. Grootenhuis, Johan van Eerden, Sybolt Harkema, David N. Reinhoudt

    Research output: Contribution to journalArticleAcademic

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    Abstract

    The conversion of 2-lithio-1,3-xylyl crown ethers (2), obtained by reaction of the 2-bromo-1,3-xylyl crown ethers (1) with n_-butyllithium at −70 °C, with an electrophile is a generally applicable method for the synthesis of 1,3-xylyl crown ethers with intraannular acidic groups.
    Original languageEnglish
    Pages (from-to)1937-1939
    JournalTetrahedron letters
    Volume28
    Issue number17
    DOIs
    Publication statusPublished - 1987

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