Intracellular Membrane Transport in Vascular Endothelial Cells

Alexander A. Mironov; Anna Mironov; Barbara Sanavio; Silke Krol; Galina V. Beznoussenko

doi:10.3390/ijms24065791

Intracellular Membrane Transport in Vascular Endothelial Cells

Alexander A. Mironov^*, Anna Mironov, Barbara Sanavio, Silke Krol, Galina V. Beznoussenko

^*Corresponding author for this work

Mesoscale Chemical Systems

Research output: Contribution to journal › Review article › Academic › peer-review

6 Citations (Scopus)

13 Downloads (Pure)

Abstract

The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs.

Original language	English
Article number	5791
Number of pages	38
Journal	International journal of molecular sciences
Volume	24
Issue number	6
DOIs	https://doi.org/10.3390/ijms24065791
Publication status	Published - Mar 2023

Keywords

endothelial cells
intra-Golgi transport
intracellular transport
micropinocytic vesicles
the Golgi complex
the kiss-and-run model
transcytosis across endothelial cells
vesicular–vacuolar organelle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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ArticleFinal published version, 6.49 MBLicence: CC BY

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title = "Intracellular Membrane Transport in Vascular Endothelial Cells",

abstract = "The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs.",

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author = "Mironov, {Alexander A.} and Anna Mironov and Barbara Sanavio and Silke Krol and Beznoussenko, {Galina V.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

doi = "10.3390/ijms24065791",

language = "English",

volume = "24",

journal = "International journal of molecular sciences",

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T1 - Intracellular Membrane Transport in Vascular Endothelial Cells

AU - Mironov, Alexander A.

AU - Mironov, Anna

AU - Sanavio, Barbara

AU - Krol, Silke

AU - Beznoussenko, Galina V.

PY - 2023/3

Y1 - 2023/3

N2 - The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs.

AB - The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs.

KW - endothelial cells

KW - intra-Golgi transport

KW - intracellular transport

KW - micropinocytic vesicles

KW - the Golgi complex

KW - the kiss-and-run model

KW - transcytosis across endothelial cells

KW - vesicular–vacuolar organelle

UR - http://www.scopus.com/inward/record.url?scp=85151107807&partnerID=8YFLogxK

U2 - 10.3390/ijms24065791

DO - 10.3390/ijms24065791

M3 - Review article

C2 - 36982865

AN - SCOPUS:85151107807

SN - 1661-6596

VL - 24

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 6

M1 - 5791

ER -

Intracellular Membrane Transport in Vascular Endothelial Cells

Abstract

Keywords

UN SDGs

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