Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging

Judith  olde Heuvel; B.J. de Wit-van der Veen; H.G. van der Poel; Marcel P.M. Stokkel; C.H. Slump

doi:10.1117/12.2542650

Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging

Judith olde Heuvel, B.J. de Wit-van der Veen, H.G. van der Poel, Marcel P.M. Stokkel, C.H. Slump

Robotics and Mechatronics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

1 Citation (Scopus)

165 Downloads (Pure)

Abstract

Intraoperative margin assessment during prostate cancer (PCa) surgery might reduce the number of positive surgical margins (PSM). Cerenkov Luminescence Imaging (CLI) based on optical imaging of PET radiopharmaceuticals is suitable for this purpose. Previous CLI research has been conducted with 18Fluorine, however, 68Gallium has more favorable CLI properties and can be coupled to a prostate cancer specific tracer: the prostate-specific membrane antigen (68Ga-PSMA). Light yield, resolution and camera sensitivity of 68Ga and 18F for CLI were investigated in a pre-clinical setting. CLI images were acquired using the LightPath system, with an exposure time of 120s, 2×2 binning and 300s, 8×8 binning. Three Eppendorf tubes (1mL) with different radioactivity concentrations (2.5, 10 and 40kBq/mL) of 18F and 68Ga were imaged. For both isotopes, an excellent linear relationship between the radioactivity concentration and detected light yield was observed (R2=0.99). 68Ga showed 22× more light yield compared to 18F, thus enabled lower detectable radioactivity concentration levels (1.2 vs. 23.7kBq/mL). Based on these promising results, a prospective feasibility study for intraoperative prostate cancer specimen CLI measurements with 68Ga-PSMA was designed and the first patients were enrolled in this study. The prostate was imaged ex vivo with the LightPath system ~70 minutes after injection of ~100MBq 68Ga-PSMA. Hotspots on the CLI images were marked for comparison with histopathology and corresponded to a PSM, defined as tumor on ink. In the first patients, CLI correctly identified all patients with a PSM. The encouraging preliminary results motivated for continuation of this trial.
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Original language	English
Title of host publication	Optics and Ionizing Radiation
Subtitle of host publication	3 February 2020, San Francisco, California, United States
Editors	Brian W. Pogue
Place of Publication	Bellingham, WA
Publisher	SPIE
ISBN (Electronic)	9781510632127
ISBN (Print)	9781510632110
DOIs	https://doi.org/10.1117/12.2542650
Publication status	Published - 2020
Event	SPIE BiOS 2020 - The Moscone Center, San Francisco, United States Duration: 1 Feb 2020 → 6 Feb 2020

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11224
ISSN (Print)	1605-7422

Conference

Conference	SPIE BiOS 2020
Country/Territory	United States
City	San Francisco
Period	1/02/20 → 6/02/20

Keywords

Prostate cancer
Cerenkov radiation imaging
Gallium
Surgery
Cerenkov luminescence imaging
Intraoperative assessment
68Ga-PSMA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.2542650

OldeHeuvel2020intraoperativeFinal published version, 1.04 MB

Cite this

olde Heuvel, J., de Wit-van der Veen, B. J., van der Poel, H. G., Stokkel, M. P. M., & Slump, C. H. (2020). Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging. In B. W. Pogue (Ed.), Optics and Ionizing Radiation: 3 February 2020, San Francisco, California, United States Article 1122407 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11224). SPIE. https://doi.org/10.1117/12.2542650

olde Heuvel, Judith ; de Wit-van der Veen, B.J. ; van der Poel, H.G. et al. / Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging. Optics and Ionizing Radiation: 3 February 2020, San Francisco, California, United States. editor / Brian W. Pogue. Bellingham, WA : SPIE, 2020. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{0cedc25394e34f309954a7eb90081842,

title = "Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging",

abstract = "Intraoperative margin assessment during prostate cancer (PCa) surgery might reduce the number of positive surgical margins (PSM). Cerenkov Luminescence Imaging (CLI) based on optical imaging of PET radiopharmaceuticals is suitable for this purpose. Previous CLI research has been conducted with 18Fluorine, however, 68Gallium has more favorable CLI properties and can be coupled to a prostate cancer specific tracer: the prostate-specific membrane antigen (68Ga-PSMA). Light yield, resolution and camera sensitivity of 68Ga and 18F for CLI were investigated in a pre-clinical setting. CLI images were acquired using the LightPath system, with an exposure time of 120s, 2×2 binning and 300s, 8×8 binning. Three Eppendorf tubes (1mL) with different radioactivity concentrations (2.5, 10 and 40kBq/mL) of 18F and 68Ga were imaged. For both isotopes, an excellent linear relationship between the radioactivity concentration and detected light yield was observed (R2=0.99). 68Ga showed 22× more light yield compared to 18F, thus enabled lower detectable radioactivity concentration levels (1.2 vs. 23.7kBq/mL). Based on these promising results, a prospective feasibility study for intraoperative prostate cancer specimen CLI measurements with 68Ga-PSMA was designed and the first patients were enrolled in this study. The prostate was imaged ex vivo with the LightPath system ~70 minutes after injection of ~100MBq 68Ga-PSMA. Hotspots on the CLI images were marked for comparison with histopathology and corresponded to a PSM, defined as tumor on ink. In the first patients, CLI correctly identified all patients with a PSM. The encouraging preliminary results motivated for continuation of this trial.{\textcopyright} (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.",

keywords = "Prostate cancer, Cerenkov radiation imaging, Gallium, Surgery, Cerenkov luminescence imaging, Intraoperative assessment, 68Ga-PSMA",

author = "{olde Heuvel}, Judith and {de Wit-van der Veen}, B.J. and {van der Poel}, H.G. and Stokkel, {Marcel P.M.} and C.H. Slump",

year = "2020",

doi = "10.1117/12.2542650",

language = "English",

isbn = "9781510632110",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Pogue, {Brian W.}",

booktitle = "Optics and Ionizing Radiation",

address = "United States",

note = "SPIE BiOS 2020 ; Conference date: 01-02-2020 Through 06-02-2020",

}

olde Heuvel, J, de Wit-van der Veen, BJ, van der Poel, HG, Stokkel, MPM & Slump, CH 2020, Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging. in BW Pogue (ed.), Optics and Ionizing Radiation: 3 February 2020, San Francisco, California, United States., 1122407, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11224, SPIE, Bellingham, WA, SPIE BiOS 2020, San Francisco, California, United States, 1/02/20. https://doi.org/10.1117/12.2542650

Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging. / olde Heuvel, Judith ; de Wit-van der Veen, B.J.; van der Poel, H.G. et al.
Optics and Ionizing Radiation: 3 February 2020, San Francisco, California, United States. ed. / Brian W. Pogue. Bellingham, WA: SPIE, 2020. 1122407 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11224).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging

AU - olde Heuvel, Judith

AU - de Wit-van der Veen, B.J.

AU - van der Poel, H.G.

AU - Stokkel, Marcel P.M.

AU - Slump, C.H.

PY - 2020

Y1 - 2020

N2 - Intraoperative margin assessment during prostate cancer (PCa) surgery might reduce the number of positive surgical margins (PSM). Cerenkov Luminescence Imaging (CLI) based on optical imaging of PET radiopharmaceuticals is suitable for this purpose. Previous CLI research has been conducted with 18Fluorine, however, 68Gallium has more favorable CLI properties and can be coupled to a prostate cancer specific tracer: the prostate-specific membrane antigen (68Ga-PSMA). Light yield, resolution and camera sensitivity of 68Ga and 18F for CLI were investigated in a pre-clinical setting. CLI images were acquired using the LightPath system, with an exposure time of 120s, 2×2 binning and 300s, 8×8 binning. Three Eppendorf tubes (1mL) with different radioactivity concentrations (2.5, 10 and 40kBq/mL) of 18F and 68Ga were imaged. For both isotopes, an excellent linear relationship between the radioactivity concentration and detected light yield was observed (R2=0.99). 68Ga showed 22× more light yield compared to 18F, thus enabled lower detectable radioactivity concentration levels (1.2 vs. 23.7kBq/mL). Based on these promising results, a prospective feasibility study for intraoperative prostate cancer specimen CLI measurements with 68Ga-PSMA was designed and the first patients were enrolled in this study. The prostate was imaged ex vivo with the LightPath system ~70 minutes after injection of ~100MBq 68Ga-PSMA. Hotspots on the CLI images were marked for comparison with histopathology and corresponded to a PSM, defined as tumor on ink. In the first patients, CLI correctly identified all patients with a PSM. The encouraging preliminary results motivated for continuation of this trial.© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

AB - Intraoperative margin assessment during prostate cancer (PCa) surgery might reduce the number of positive surgical margins (PSM). Cerenkov Luminescence Imaging (CLI) based on optical imaging of PET radiopharmaceuticals is suitable for this purpose. Previous CLI research has been conducted with 18Fluorine, however, 68Gallium has more favorable CLI properties and can be coupled to a prostate cancer specific tracer: the prostate-specific membrane antigen (68Ga-PSMA). Light yield, resolution and camera sensitivity of 68Ga and 18F for CLI were investigated in a pre-clinical setting. CLI images were acquired using the LightPath system, with an exposure time of 120s, 2×2 binning and 300s, 8×8 binning. Three Eppendorf tubes (1mL) with different radioactivity concentrations (2.5, 10 and 40kBq/mL) of 18F and 68Ga were imaged. For both isotopes, an excellent linear relationship between the radioactivity concentration and detected light yield was observed (R2=0.99). 68Ga showed 22× more light yield compared to 18F, thus enabled lower detectable radioactivity concentration levels (1.2 vs. 23.7kBq/mL). Based on these promising results, a prospective feasibility study for intraoperative prostate cancer specimen CLI measurements with 68Ga-PSMA was designed and the first patients were enrolled in this study. The prostate was imaged ex vivo with the LightPath system ~70 minutes after injection of ~100MBq 68Ga-PSMA. Hotspots on the CLI images were marked for comparison with histopathology and corresponded to a PSM, defined as tumor on ink. In the first patients, CLI correctly identified all patients with a PSM. The encouraging preliminary results motivated for continuation of this trial.© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

KW - Prostate cancer

KW - Cerenkov radiation imaging

KW - Gallium

KW - Surgery

KW - Cerenkov luminescence imaging

KW - Intraoperative assessment

KW - 68Ga-PSMA

U2 - 10.1117/12.2542650

DO - 10.1117/12.2542650

M3 - Conference contribution

SN - 9781510632110

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optics and Ionizing Radiation

A2 - Pogue, Brian W.

PB - SPIE

CY - Bellingham, WA

T2 - SPIE BiOS 2020

Y2 - 1 February 2020 through 6 February 2020

ER -

olde Heuvel J, de Wit-van der Veen BJ, van der Poel HG, Stokkel MPM, Slump CH. Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging. In Pogue BW, editor, Optics and Ionizing Radiation: 3 February 2020, San Francisco, California, United States. Bellingham, WA: SPIE. 2020. 1122407. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2542650

Intraoperative specimen assessment in prostate cancer surgery using Cerenkov luminescence imaging

Abstract

Publication series

Conference

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this