Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy

M. Talelli, S. Oliveira, C.J. Rijcken, E.H. Pieters, T. Etrych, K. Ulbrich, C.F. van Nostrum, Gerrit Storm, W.E. Hennink, Twan Gerardus Gertudis Maria Lammers

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Various different passively and actively targeted nanomedicines have been designed and evaluated over the years, in particular for the treatment of cancer. Reasoning that the potential of ligand-modified nanomedicines can be substantially improved if intrinsically active targeting moieties are used, we have here set out to assess the in vivo efficacy of nanobody-modified core-crosslinked polymeric micelles containing covalently entrapped doxorubicin. Nanobody-modified polymeric micelles were found to inhibit tumor growth even in the absence of a drug, and nanobody-modified micelles containing doxorubicin were significantly more effective than nanobody-free micelles containing doxorubicin. Based on these findings, we propose that the combination of two therapeutic strategies within one nanomedicine formulation, i.e. the intrinsic pharmacological activity of ligand-modified carrier materials with the cytostatic activity of the incorporated chemotherapeutic agents, is a highly promising approach for improving the efficacy of tumor-targeted combination therapy
Original languageUndefined
Pages (from-to)1255-1260
Issue number4
Publication statusPublished - 2013


  • METIS-301782
  • IR-90151

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