TY - JOUR
T1 - Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design
AU - Hesselmann, Felix
AU - Focke, Jannis M.
AU - Schlanstein, Peter C.
AU - Steuer, Niklas
AU - Reinartz, Sebastian D.
AU - Schmitz-Rode, Thomas
AU - Steinseifer, Ulrich
AU - Jansen, Sebastian V.
AU - Arens, Jutta
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Currently, artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers, achieving diffusive gas exchange. At both ends of the fibers, the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood phase. During a uniaxial centrifugation process, the glue forms the “potting.” The shape of the cured potting is then determined by the centrifugation process, limiting design possibilities and leading to unfavorable stagnation zones associated with blood clotting. In this study, a new multiaxial centrifugation process was developed, expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting margins. Two-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets. A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs, resulting in good agreement with the simulations. In summary, this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes, eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.
AB - Currently, artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers, achieving diffusive gas exchange. At both ends of the fibers, the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood phase. During a uniaxial centrifugation process, the glue forms the “potting.” The shape of the cured potting is then determined by the centrifugation process, limiting design possibilities and leading to unfavorable stagnation zones associated with blood clotting. In this study, a new multiaxial centrifugation process was developed, expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting margins. Two-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets. A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs, resulting in good agreement with the simulations. In summary, this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes, eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.
KW - Manufacturing
KW - Potting process
KW - Hollow fiber membrane module
KW - artificial lung
KW - Membrane lung
KW - Flow design
U2 - 10.1007/s42242-021-00139-2
DO - 10.1007/s42242-021-00139-2
M3 - Article
VL - 5
SP - 141
EP - 152
JO - Bio-Design and Manufacturing
JF - Bio-Design and Manufacturing
SN - 2096-5524
ER -