Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement

Wouter J.E.M. Habraken, Zheng Zhang, Joop G.C. Wolke, Dirk W. Grijpma, Antonios G. Mikos, Jan Feijen, John A. Jansen

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Abstract

Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polyester with rubber-like properties. Introduction of this polymer into an injectable calcium phosphate bone cement can therefore be used to introduce macroporosity into the cement for tissue engineering purposes as well as to improve mechanical properties. Aim of this study was to investigate calcium phosphate cements with incorporated PTMC microspheres (PTMC CPCs) on their physical/mechanical properties and in vitro degradation characteristics. Therefore, composites were tested on setting time and mechanical strength as well as subjected to phosphate buffered saline (PBS) and enzyme containing medium. PTMC CPCs (12.5 and 25 wt%) with molecular weights of 52.7 kg mol−1 and 176.2 kg mol−1 were prepared, which showed initial setting times similar to that of original CPC. Though compression strength decreased upon incorporation of PTMC microspheres, elastic properties were improved as strain-at-yield increased with increasing content of microspheres. Sustained degradation of the microspheres inside PTMC CPC occurred when incubated in the enzymatic environment, but not in PBS, which resulted in an interconnected macroporosity for the 25 wt% composites.
Original languageEnglish
Pages (from-to)2464-2476
JournalBiomaterials
Volume29
Issue number16
DOIs
Publication statusPublished - 2008

Fingerprint

Calcium phosphate
Microspheres
Carbonates
Cements
Injections
Phosphates
Degradation
Bone cement
Mechanical properties
Bone Cements
Polyesters
Rubber
Composite materials
Tissue Engineering
Tissue engineering
Strength of materials
calcium phosphate
polytrimethylene carbonate
Polymers
Compaction

Keywords

  • METIS-254030
  • IR-68974

Cite this

Habraken, Wouter J.E.M. ; Zhang, Zheng ; Wolke, Joop G.C. ; Grijpma, Dirk W. ; Mikos, Antonios G. ; Feijen, Jan ; Jansen, John A. / Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement. In: Biomaterials. 2008 ; Vol. 29, No. 16. pp. 2464-2476.
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abstract = "Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polyester with rubber-like properties. Introduction of this polymer into an injectable calcium phosphate bone cement can therefore be used to introduce macroporosity into the cement for tissue engineering purposes as well as to improve mechanical properties. Aim of this study was to investigate calcium phosphate cements with incorporated PTMC microspheres (PTMC CPCs) on their physical/mechanical properties and in vitro degradation characteristics. Therefore, composites were tested on setting time and mechanical strength as well as subjected to phosphate buffered saline (PBS) and enzyme containing medium. PTMC CPCs (12.5 and 25 wt{\%}) with molecular weights of 52.7 kg mol−1 and 176.2 kg mol−1 were prepared, which showed initial setting times similar to that of original CPC. Though compression strength decreased upon incorporation of PTMC microspheres, elastic properties were improved as strain-at-yield increased with increasing content of microspheres. Sustained degradation of the microspheres inside PTMC CPC occurred when incubated in the enzymatic environment, but not in PBS, which resulted in an interconnected macroporosity for the 25 wt{\%} composites.",
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Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement. / Habraken, Wouter J.E.M.; Zhang, Zheng; Wolke, Joop G.C.; Grijpma, Dirk W.; Mikos, Antonios G.; Feijen, Jan; Jansen, John A.

In: Biomaterials, Vol. 29, No. 16, 2008, p. 2464-2476.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement

AU - Habraken, Wouter J.E.M.

AU - Zhang, Zheng

AU - Wolke, Joop G.C.

AU - Grijpma, Dirk W.

AU - Mikos, Antonios G.

AU - Feijen, Jan

AU - Jansen, John A.

PY - 2008

Y1 - 2008

N2 - Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polyester with rubber-like properties. Introduction of this polymer into an injectable calcium phosphate bone cement can therefore be used to introduce macroporosity into the cement for tissue engineering purposes as well as to improve mechanical properties. Aim of this study was to investigate calcium phosphate cements with incorporated PTMC microspheres (PTMC CPCs) on their physical/mechanical properties and in vitro degradation characteristics. Therefore, composites were tested on setting time and mechanical strength as well as subjected to phosphate buffered saline (PBS) and enzyme containing medium. PTMC CPCs (12.5 and 25 wt%) with molecular weights of 52.7 kg mol−1 and 176.2 kg mol−1 were prepared, which showed initial setting times similar to that of original CPC. Though compression strength decreased upon incorporation of PTMC microspheres, elastic properties were improved as strain-at-yield increased with increasing content of microspheres. Sustained degradation of the microspheres inside PTMC CPC occurred when incubated in the enzymatic environment, but not in PBS, which resulted in an interconnected macroporosity for the 25 wt% composites.

AB - Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polyester with rubber-like properties. Introduction of this polymer into an injectable calcium phosphate bone cement can therefore be used to introduce macroporosity into the cement for tissue engineering purposes as well as to improve mechanical properties. Aim of this study was to investigate calcium phosphate cements with incorporated PTMC microspheres (PTMC CPCs) on their physical/mechanical properties and in vitro degradation characteristics. Therefore, composites were tested on setting time and mechanical strength as well as subjected to phosphate buffered saline (PBS) and enzyme containing medium. PTMC CPCs (12.5 and 25 wt%) with molecular weights of 52.7 kg mol−1 and 176.2 kg mol−1 were prepared, which showed initial setting times similar to that of original CPC. Though compression strength decreased upon incorporation of PTMC microspheres, elastic properties were improved as strain-at-yield increased with increasing content of microspheres. Sustained degradation of the microspheres inside PTMC CPC occurred when incubated in the enzymatic environment, but not in PBS, which resulted in an interconnected macroporosity for the 25 wt% composites.

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