Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement

Wouter J.E.M. Habraken, Zheng Zhang, Joop G.C. Wolke, Dirk W. Grijpma, Antonios G. Mikos, Jan Feijen, John A. Jansen

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Abstract

Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polyester with rubber-like properties. Introduction of this polymer into an injectable calcium phosphate bone cement can therefore be used to introduce macroporosity into the cement for tissue engineering purposes as well as to improve mechanical properties. Aim of this study was to investigate calcium phosphate cements with incorporated PTMC microspheres (PTMC CPCs) on their physical/mechanical properties and in vitro degradation characteristics. Therefore, composites were tested on setting time and mechanical strength as well as subjected to phosphate buffered saline (PBS) and enzyme containing medium. PTMC CPCs (12.5 and 25 wt%) with molecular weights of 52.7 kg mol−1 and 176.2 kg mol−1 were prepared, which showed initial setting times similar to that of original CPC. Though compression strength decreased upon incorporation of PTMC microspheres, elastic properties were improved as strain-at-yield increased with increasing content of microspheres. Sustained degradation of the microspheres inside PTMC CPC occurred when incubated in the enzymatic environment, but not in PBS, which resulted in an interconnected macroporosity for the 25 wt% composites.
Original languageEnglish
Pages (from-to)2464-2476
JournalBiomaterials
Volume29
Issue number16
DOIs
Publication statusPublished - 2008

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Keywords

  • METIS-254030
  • IR-68974

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