The 2011 Special Issue of Macromolecular Symposia discussed papers presented at the Advanced Functional Polymers for Medicine conference that was held at the University of Twente campus in Enschede, the Netherlands, from June 15-17, 2011. An approach of surface-initiated atom transfer radical polymerization and photo-induced polymerization of 2-methacryloyloxyethyl phosphorylcholine onto polycarbonateurethanes is described by Feng and co-workers. Electrospun fibers and films of poly(ether)ester urethanes based on poly( p-dioxanone)diol and poly(e-caprolactone) diol were investigated by Schneider and researchers. Lange and colleagues presented a synthetic method for preparing PEIs with lower glass transition temperatures, which would enable materials with higher flexibility. A method of creating flexible polycyanoacrylate-based materials is reported by Tripodo and researchers. Cajot and coworkers describe novel micelles composed of star-shaped copolymers based on PEG and PCL.